Evidence map›Paper›PMID 40154872›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2025

Associations between urinary polycyclic aromatic hydrocarbon biomarker concentrations and birth outcomes in the LIFECODES cohort.

Amber L Cathey, Jarrod L Eaton, Deborah J Watkins, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, John D Meeker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amber L CatheyDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Jarrod L EatonDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Deborah J WatkinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Kelly K FergusonEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.
David E CantonwineDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02115, USA.
Thomas F McElrathDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02115, USA.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA. Electronic address: meekerj@umich.edu.

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Environmental PAH exposure and preeclampsia risk: Investigation of PE subtypes and the role of inflammation and oxidative stress.R01ES031591 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John D. Meeker · 2021 to 2026
$3.9M
NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES031591
6 · The paper itself

Abstract

Environmental exposure to polycyclic aromatic hydrocarbons (PAH) is ubiquitous and may impact fetal development leading to adverse birth outcomes. PAHs result from incomplete combustion and exposure sources include inhalation of cigarette smoke and car exhaust, ingestion of charred meat, and many others. The purpose of this study was to determine associations between prenatal PAH biomarker concentrations and birth outcomes. Our nested case-control study included 123 preterm birth cases and 335 term controls from the LIFECODES cohort between 2006 and 2008 (n = 458). Eight urinary PAH metabolites were measured in urine samples collected at up to four study visits (median 12, 18, 24, 34 weeks gestation). Linear and logistic regression were used to model gestational geometric mean PAH biomarker concentrations in relation to preterm birth, birth weight z-score, and small or large for gestational age with adjustment for potential confounders. Effect modification by infant sex was also explored. Odds ratios for preterm birth were elevated for most PAH metabolites but confidence intervals included the null. For most PAH metabolites, a significant inverse association was observed for birth weight for gestational age z-score, and a corresponding increase in the odds of small for gestational age (SGA). For example, an interquartile range increase in 2-hydroxynapthalene (2-NAP) was associated with a significantly lower birth weight z-score (β: 0.22; 95 % CI: 0.36, -0.08) and 1.90 times the odds of SGA (95 %CI: 1.41, 2.55). Further study should aim to determine the extent and mechanisms by which PAH exposure impacts fetal growth.

Indexed as

Environmental PollutantsMaternal ExposurePolycyclic Aromatic HydrocarbonsAdultBiomarkersBirth WeightCase-Control StudiesCohort StudiesEnvironmental ExposureFemaleHumansInfant, NewbornInfant, Small for Gestational AgeMalePregnancyPremature BirthBiomarkersEnvironmental PollutantsPolycyclic Aromatic HydrocarbonsBiomarkersBirth sizeFetal growthPolycyclic aromatic hydrocarbonsPregnancy epidemiology

Identifiers

PMID40154872
PMCPMC12009183

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.