Evidence map›Paper›PMID 40154726›Full record

ArticleExperimental eye research2025

Aging affects retinal oxygen and blood flow metrics in mice.

Farzan Abdolahi, Mansour Rahimi, Rutuja Zinjal, Sava Sakadzic, Mahnaz Shahidi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Farzan AbdolahiDepartment of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, CA, United States.
Mansour RahimiDepartment of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, CA, United States.
Rutuja ZinjalDepartment of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, CA, United States.
Sava SakadzicAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Mahnaz ShahidiDepartment of Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, CA, United States; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States. Electronic address: mshahidi@usc.edu.

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Noninvasive Imaging of Chorioretinal Oxygen TensionR01EY017918 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHAHIDI, MAHNAZ · 2007 to 2022
$6.2M
Two-photon Imaging of Oxygen and Blood Flow in Retinal and Cerebral VasculatureRF1NS121095 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA, SHAHIDI, MAHNAZ · 2021 to 2021
$1.9M
Two-photon Imaging of Oxygen and Blood Flow in Retinal and Cerebral VasculatureR01NS121095 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Sava Sakadzic, Mahnaz Shahidi · 2024 to 2026
$1.3M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY017918NINDS NIH HHS R01 NS121095NINDS NIH HHS RF1 NS121095
6 · The paper itself

Abstract

purposeAging affects the eyes and is a major risk factor for ocular diseases. The purpose of this study was to determine the effect of age on retinal oxygen and blood flow metrics in mice.

methodsForty-seven C57BL/6 mice were included in four age groups (3-month-old (m): N = 18, 9m: N = 13, 15m: N = 8, and 21m: N = 8). Retinal arterial and venous diameters (D

resultsWe found significant differences in V

conclusionsOur results showed that retinal vascular oxygen content, oxygen delivery rate, and blood flow were significantly reduced in older mice and established baselines for retinal physiological biomarkers according to age.

Indexed as

AgingOxygenOxygen ConsumptionRegional Blood FlowRetinal ArteryRetinal VeinRetinal VesselsAnimalsBlood Flow VelocityMaleMiceMice, Inbred C57BLOxygen SaturationOxygenAgingBlood flowOxygenRetinaRetinal blood vesselsRetinal imagingRetinal vasculature

Identifiers

PMID40154726
PMCPMC12058383

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.