ArticleInternational journal of biological macromolecules2025
Fabrication of pullulan-chitosan fiber membranes for enhanced hemostatic applications.
Article in International journal of biological macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Biodegradable PCL-PLGA Electrospun Nanofibers for Localized Cancer Therapy.ACS applied bio materials · 2026Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
Pullulan-based fibers blended with chitosan (Chi) were developed using a rotational spinning method for potential biomedical applications. Aqueous precursor formulations containing 15 % by weight in pullulan and varying Chi concentrations (6 % and 7 %) were optimized to produce nanofibers at elevated temperatures and rotational speeds exceeding 7 k rpm. The highest fiber production yields of approximately 90 % and 65 % were achieved at 13 k rpm for the 6 % and 7 % Chi formulations, respectively. The pullulan-chitosan fibers were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, dynamic mechanical analyzer, powder X-ray diffraction, and rheological property measurements. Morphological analyses revealed nanometric fiber diameters and a decrease in bead formation with increasing rotational speeds. Thermal stability studies, conducted via thermogravimetric and differential thermal analyses, showed that the composite fibers exhibited intermediate degradation behaviors between their individual polymer components, indicating good integration of Chi into the pullulan matrix. Elemental analysis confirmed the successful incorporation of Chi into the fibers, with nitrogen content closely matching theoretical predictions. Functional assessments demonstrated the hemocompatibility of the Pull-Chi fibers with hemolysis rates below 1 %. Additionally, the fibers exhibited superior hemostatic potential, effectively promoting blood clotting in vitro testing. These findings underscore the promise of Pull-Chi fibers as multifunctional biomaterials for applications in wound healing and tissue engineering. Future studies involving animal models are warranted to validate their clinical potential.
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Registered trials
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