Evidence map›Paper›PMID 40154614›Full record

ArticleThe Journal of biological chemistry2025

Conversion of glutamate into proline by the leucine analog BCH enhances biphasic insulin secretion in pancreatic β-cells.

Sevda Gheibi, Luis Rodrigo Cataldo, Hamidreza Ardalani, Lisa Nocquet, Peter Spégel, Susanne G Straub, Geoffrey W G Sharp, Malin Fex, Hindrik Mulder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sevda GheibiUnit of Molecular Metabolism, Lund University Diabetes Centre, Malmö, Sweden. Electronic address: Sevda.gheibi@med.lu.se.
Luis Rodrigo CataldoUnit of Molecular Metabolism, Lund University Diabetes Centre, Malmö, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hamidreza ArdalaniDepartment of Chemistry, Centre for Analysis and Synthesis, Lund University, Lund, Sweden; Pharmacokinetics, Dynamics, and Metabolism, Pfizer R&D, Pfizer Inc., Bothell, Washington, USA.
Lisa NocquetUnit of Molecular Metabolism, Lund University Diabetes Centre, Malmö, Sweden.
Peter SpégelDepartment of Chemistry, Centre for Analysis and Synthesis, Lund University, Lund, Sweden.
Susanne G StraubDepartment of Molecular Medicine, Cornell University, Ithaca, New York, USA.
Geoffrey W G SharpDepartment of Molecular Medicine, Cornell University, Ithaca, New York, USA.
Malin FexUnit of Molecular Metabolism, Lund University Diabetes Centre, Malmö, Sweden.
Hindrik MulderUnit of Molecular Metabolism, Lund University Diabetes Centre, Malmö, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biphasic insulin secretion, which fails in type 2 diabetes, can be provoked by various nutrient stimuli, glucose being the superior physiological one. To identify pathways that may play a role in β-cell stimulus-secretion coupling, we compared β-cell and islet functional, secretory, and metabolic responses to glucose and 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), a leucine analog, that acts as an allosteric activator of glutamate dehydrogenase. We employed a range of techniques, including insulin secretion assays, mitochondrial activity measurements, ATP/ADP ratio assessments, and cytosolic Ca

Indexed as

Glutamic AcidInsulinInsulin-Secreting CellsLeucineProlineAdenosine TriphosphateAldehyde DehydrogenaseAnimalsCalciumGlucoseHumansInsulin SecretionMiceMitochondriaRatsAdenosine TriphosphateAldehyde DehydrogenaseCalciumGlucoseGlutamic AcidInsulinLeucineProlineBCHglutamate dehydrogenaseinsulin secretionprolineβ-cells

Identifiers

PMID40154614
PMCPMC12059337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.