Evidence map›Paper›PMID 40154492›Full record

Trial reportCell reports. Medicine2025

Common and specific effects in brain oscillations and motor symptoms of tDCS and tACS in Parkinson's disease.

Jiafang Liu, Ying Zhu, Biao Chen, Qiujian Meng, Panpan Hu, Xianwen Chen, Junjie Bu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05678725 (Comparison of Transcranial Direct Current Stimulation and Transcranial Alternating Current Stimulation Treatments in Improving the Motor Performance in Parkinson's Disease), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05678725 nacompletednot on this map

Comparison of Transcranial Direct Current Stimulation and Transcranial Alternating Current Stimulation Treatments in Improving the Motor Performance in Parkinson's Disease

TypeinterventionalSponsorAnhui Medical UniversityRan2023 to 2024Enrolled60ConditionstACS, tDCSArmstACS, tDCS, sham
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Variable E-field properties of dual-site tACS with phase lags.Imaging neuroscience (Cambridge, Mass.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiafang LiuSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Ying ZhuSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Biao ChenDepartment of Medical Engineering, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Qiujian MengSchool of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
Panpan HuFirst Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Xianwen ChenFirst Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Junjie BuThe First Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230032, China; School of Biomedical Engineering, Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei 230032, China. Electronic address: bujunjie@ahmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) leads to neurodegeneration and abnormal brain oscillations, causing motor dysfunction. Transcranial stimulation (transcranial direct current stimulation [tDCS]/transcranial alternating current stimulation [tACS]) may alleviate symptoms, but their oscillatory modulation mechanisms remain unclear. This randomized controlled trial (RCT) examines the effects of single-session tDCS/tACS on 60 PD patients, assigned to tDCS, tACS (20 Hz), or sham groups. Each receives 20-min left motor cortex stimulation while performing a simple reaction task. Open-source resting-state electroencephalogram (EEG) data reveal increased theta and decreased beta power in PD. In the RCT, tDCS and tACS enhance beta power, improving rigidity and bradykinesia. Additionally, tDCS reduces theta power, specifically alleviating tremor symptoms. Notably, the theta/beta ratio predicts and mediates tremor changes induced by tDCS more effectively than theta power alone. This sutdy revealed that tDCS broadly modulates oscillations, improving multiple symptoms, while tACS targets a single oscillation for specific symptom relief, emphasizing the crucial role of diverse oscillations in PD motor pathophysiology. This study was registered at ClinicalTrials.gov (NCT05678725).

Indexed as

BrainParkinson DiseaseTranscranial Direct Current StimulationAgedElectroencephalographyFemaleHumansHypokinesiaMaleMiddle AgedMotor CortexTheta RhythmTremorbrain stimulationmotor symptomsneuromodulationoscillationParkinson’s diseasetACStDCStranscranial alternating current stimulationtranscranial direct current stimulationtranscranial electrical stimulation

Identifiers

PMID40154492
PMCPMC12047527

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.