Evidence map›Paper›PMID 40154490›Full record

ArticleCell host & microbe2025

Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis.

Wioletta Lisicka, Zachary M Earley, Joseph J Sifakis, Steven A Erickson, Jonathan R Mattingly, Natalie J Wu-Woods, Siddharth R Krishnamurthy, Yasmine Belkaid, Rustem F Ismagilov, Jason G Cyster and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Gut virome dynamics: from commensal to critical player in health and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Dietary supplementation withFrontiers in microbiology · 2026
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wioletta LisickaCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA.
Zachary M EarleyCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Joseph J SifakisDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Steven A EricksonCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
Jonathan R MattinglyCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
Natalie J Wu-WoodsDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Siddharth R KrishnamurthyMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Rustem F IsmagilovDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jason G CysterDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Samantha J RiesenfeldCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.
Albert BendelacCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA.
Bana JabriCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Paris City University, Imagine Institute, Paris, France. Electronic address: bjabri@bsd.uchicago.edu.

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Innate and adaptive immunity in celiac diseaseR01DK067180 · NIDDK · UNIVERSITY OF CHICAGO · PI JABRI, BANA · 2005 to 2024
$8.5M
Transcriptional Regulation of Innate-Like T CellsR01AI038339 · NIAID · UNIVERSITY OF CHICAGO · PI ESTERHAZY, DARIA · 1996 to 2025
$7.6M
Transcriptional Regulation of Innate-Like T CellsR37AI038339 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2017 to 2023
$3.4M
Academic Rheumatology and Clinical ImmunologyT32AR079068 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jinoos Yazdany, JULIE ZIKHERMAN · 2021 to 2026
$2.5M
NIAID NIH HHS R01 AI038339NIAID NIH HHS R37 AI038339NIAID NIH HHS T32 AI007334NIAMS NIH HHS T32 AR079068NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK067180
6 · The paper itself

Abstract

Immunoglobulin A (IgA) is the predominant immunoglobulin isotype in mammals, primarily secreted at type I mucosal surfaces. Despite its abundance, the precise role of secretory IgA in the intestinal lumen, where it coats a diverse array of commensal microbiota, has remained elusive. Our study reveals that germinal center IgA responses are essential for preventing chronic colonization of the gut by specific viruses. In the absence of IgA, chronic viral colonization triggers an antigen-driven expansion of CD8αβ

Indexed as

HomeostasisImmunoglobulin AIntestinesAnimalsColitisGerminal CenterIgA DeficiencyInterferon Type IIntestinal MucosaIntraepithelial LymphocytesMiceMice, Inbred C57BLImmunoglobulin AInterferon Type IAstroviruscolitisimmunoglobulin Aintraepithelial lymphocytesΝorovirus

Identifiers

PMID40154490
PMCPMC12235565

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.