Evidence map›Paper›PMID 40154478›Full record

ArticleStem cell reports2025

Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis.

Christopher A Procyk, Anna Melati, Joana Ribeiro, Jingshu Liu, Matthew J Branch, Jamie D Delicata, Menahil Tariq, Aikaterini A Kalarygrou, Jessica Kapadia, Majid Moshtagh Khorsani and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Restoring Sight: The Journey of AIPL1 from Discovery to Therapy.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christopher A ProcykOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Anna MelatiOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Joana RibeiroOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Jingshu LiuOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Matthew J BranchOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Jamie D DelicataOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Menahil TariqOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Aikaterini A KalarygrouOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Jessica KapadiaOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Majid Moshtagh KhorsaniOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Emma L WestOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Alexander J SmithOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Anai Gonzalez-CorderoOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Robin R AliOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK.
Rachael A PearsonOcular Cell and Gene Therapy Group, Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, London SE1 9RT, UK. Electronic address: rachael.pearson@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoreceptor degeneration is a leading cause of untreatable sight loss. Previously, we showed that human pluripotent stem cell-derived cone photoreceptors (hCones) can rescue retinal function in the Rd1 mouse model of rod-cone dystrophy. However, retinal degenerations display markedly different severities and concomitant remodeling of the remaining retina; for photoreceptor replacement therapy to be broadly effective, it must work for a variety of disease phenotypes. Here, we sought to rescue the Aipl1

Indexed as

Adaptor Proteins, Signal TransducingEye ProteinsLeber Congenital AmaurosisRetinal Cone Photoreceptor CellsAnimalsCalmodulin-Binding ProteinsDisease Models, AnimalHumansMicePluripotent Stem CellsAdaptor Proteins, Signal TransducingAIPL1 protein, humanCalmodulin-Binding ProteinsEye Proteinsblindnessdegenerationfunctionmacularorganoidphotoreceptorrescuesynapsetherapytransplant

Identifiers

PMID40154478
PMCPMC12069896

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.