Evidence map›Paper›PMID 40154320›Full record

ArticleJournal of the American Veterinary Medical Association2025

Copper and manganese levels are associated with infectious abortions, stillbirths, and early neonatal deaths in upper Midwest beef cattle herds.

Heather Mitchell, Heidi L Pecoraro, Brett T Webb, Bong-Jin Choi, Chamari Idamawatta, Michelle S Mostrom, Quynn P Steichen, Karl Hoppe

Abstract read
In one paragraph

Article in Journal of the American Veterinary Medical Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heather MitchellAgricultural Experiment Station, Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND.
Heidi L PecoraroAgricultural Experiment Station, Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND.
Brett T WebbAgricultural Experiment Station, Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND.
Bong-Jin ChoiDepartment of Statistics, North Dakota State University, Fargo, ND.
Chamari IdamawattaDepartment of Statistics, North Dakota State University, Fargo, ND.
Michelle S MostromAgricultural Experiment Station, Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND.
Quynn P SteichenAgricultural Experiment Station, Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND.
Karl HoppeCarrington Research Extension Center, North Dakota State University, Carrington, ND.

Funding

Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Sanku Mallik · 2016 to 2026
$20.5M
NIGMS NIH HHS P20 GM109024
6 · The paper itself

Abstract

Objective: To determine the incidence of select mineral and vitamin deficiencies in beef cattle abortions, stillbirths, and neonates less than 24 hours old and to evaluate whether nutrient deficiencies are associated with causes of abortion. Methods: A retrospective study of abortion cases from laboratory-performed necropsies and field-collected tissues submitted to the North Dakota State University Veterinary Diagnostic Laboratory over a 5-year period was conducted. Abortion investigations included gross and microscopic examinations, bacterial and fungal cultures, PCR assays, and quantitative analysis of the liver for copper, manganese, zinc, iron, selenium, cobalt, vitamin A, and vitamin E. Fisher exact tests, χ2 tests, and logistic regression analyses were performed to evaluate associations between minerals and vitamins and causes of abortion. Results: Of 251 animals, 34% of abortion cases were attributable to a known cause. All but 4 animals were late gestational or full term. There was no sex predilection. When evaluated independently, minerals and vitamins were not associated with whether the cause of abortion was known. However, using logistic regression with mineral concentration (wet weight), there was an increased risk of infectious abortion with lower levels of fetal liver copper and higher levels of fetal liver manganese. Conclusions: Copper and manganese levels are associated with infectious abortions, stillbirths, and neonatal deaths within 24 hours of birth in upper Midwest beef cattle herds. Incorporating liver trace mineral analysis into abortion investigations is crucial for a comprehensive diagnostic strategy. Clinical Relevance: Practitioners should consider the impact of mineral status when evaluating the cause of abortion in beef cattle.

Indexed as

Abortion, VeterinaryCattle DiseasesCopperManganeseStillbirthAnimalsAnimals, NewbornCattleFemaleLiverMalePerinatal DeathPregnancyRetrospective StudiesCopperManganesebovine abortioncoppermanganesemineral deficiencyvitamin deficiency

Identifiers

PMID40154320
PMCPMC12085280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.