Evidence map›Paper›PMID 40154156›Full record

ArticlePublic health2025

Combined effects of life course maternal psychosocial experiences on perinatal mental health.

Katherine Bowers, Robert T Ammerman, Lili Ding, Kimberly Yolton, Jennifer R Frey, Alonzo T Folger

Abstract read
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In one paragraph

Article in Public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katherine BowersDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: Katherine.bowers@cchmc.org.
Robert T AmmermanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Every Child Succeeds, Cincinnati, OH, USA.
Lili DingDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kimberly YoltonDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jennifer R FreyDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Every Child Succeeds, Cincinnati, OH, USA.
Alonzo T FolgerDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Every Child Succeeds, Cincinnati, OH, USA.

Funding

11/15/18. Bowers. Resub R01. Linking pre- and post-natal psychosocial determinants, DNA methylation, and early developmental health disparitiesR01MD013006 · NIMHD · CINCINNATI CHILDRENS HOSP MED CTR · PI BOWERS, KATHERINE A, FOLGER, ALONZO T · 2019 to 2023
$3.1M
NIMHD NIH HHS R01 MD013006
6 · The paper itself

Abstract

objectivesIdentifying experiences that place women at higher risk for mental health impairment is critical to inform perinatal care. This study's purpose was to identify the individual and combined association between early life adversity, discrimination, and perinatal mental health. STUDY

designProspective cohort study.

methodsThe Pregnancy and Infant Development Study (PRIDE) is a prospective cohort study that follows pregnant women in Cincinnati, Ohio through 18 months postnatal. Measures of socioeconomic factors, adverse childhood experiences, discrimination, and maternal mental health were collected at home study visits. Multiple linear regression identified associations between psychosocial measures and perinatal mental health.

resultsAdjusting for socioeconomic factors, early life adversity, and discrimination were significantly associated with perinatal mental health (β range from 0.20 to 1.64). The strongest association was observed for the association between emotional neglect and depression β = 2.53 (p = 0.006). The joint effect of high early adversity and high discrimination demonstrated the strongest effect.

conclusionWomen who experienced early life trauma, in particular emotional neglect and discrimination, also experienced depression and distress during the perinatal period. Identification of women at risk for mental health problems should be a priority for programs that are positioned to help mitigate future consequences to mothers and their families.

Indexed as

Adverse Childhood ExperiencesMental DisordersMental HealthMothersAdultDepressionFemaleHumansOhioPregnancyProspective StudiesSocioeconomic FactorsYoung AdultAdversityDiscriminationMaternal healthPerinatal mental health

Identifiers

PMID40154156
PMCPMC12207680

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.