ArticleMedicine2025
Neurofibromatosis type 1 accompanied by acromelanoma: A case report.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
rationaleNeurofibromatosis is an autosomal dominant genetic disorder characterized by developmental abnormalities of the nervous system, skin, and bones. Clinically, it is relatively rare and is often associated with various benign and malignant tumors. PATIENT CONCERNS: However, reports of its association with malignant melanoma are scarce, and has been reported as a case report in this study. Case reports and treatment options are discussed below. DIAGNOSES: A 71-year-old male presented with long-standing skin nodules and plaques including a growing and itchy black patch on his left heel. Pathological examination revealed neurofibroma in the nodules and malignant melanoma in the heel lesion. The diagnosis was neurofibromatosis type l with acromelanoma.
interventionsDue to financial constraints, the patient refused surgical excision of the tumor and opted for conservative treatment with interferon injections. OUTCOMES: The patient is currently under follow-up observation. LESSONS: This rare case underscores the importance of monitoring genetic disorder patients for tumor risk, emphasizing timely intervention.
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