Evidence map›Paper›PMID 40153458›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate.

Weiling Huang, Xingxing Zhong, Cleidiane G Zampronio, Andrew R Bottrill, Kite G E Jones, Ana B Tinoco, Lijin Guo, Michaela Egertová, Olivier Mirabeau, Maurice R Elphick

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weiling HuangCentre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.ORCID 0000-0001-9395-2200
Xingxing ZhongCentre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
Cleidiane G ZampronioProteomics Facility Research Technology Platform, School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0003-0934-0792
Andrew R BottrillProteomics Facility Research Technology Platform, School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0002-5182-3643
Kite G E JonesCentre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
Ana B TinocoCentre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
Lijin GuoCollege of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0001-5919-9980
Michaela EgertováCentre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
Olivier MirabeauBrain-Immune Communication Lab, Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Inserm U1224, Paris 75015, France.ORCID 0000-0002-4048-1385
Maurice R ElphickCentre for Evolutionary and Functional Genomics, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.ORCID 0000-0002-9169-0048

Funding

Leverhulme Trust RPG-2018-200UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X001024/1Wellcome Trust
6 · The paper itself

Abstract

Neuropeptide signaling systems are key regulators of physiological and behavioral processes in animals. However, the evolutionary history of some neuropeptides originally discovered in vertebrates is unknown. The peptide bombesin (BN) was first isolated from the skin of the toad

Indexed as

AsteriasBombesinNeuropeptidesSignal TransductionAmino Acid SequenceAnimalsGastrin-Releasing PeptideNeurokinin BPhylogenyReceptors, BombesinBombesinGastrin-Releasing PeptideNeurokinin Bneuromedin BNeuropeptidesReceptors, BombesinAsterias rubensbombesinechinodermG protein–coupled receptorneuropeptide

Identifiers

PMID40153458
PMCPMC12002301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.