Evidence map›Paper›PMID 40153436›Full record

ArticleCell reports2025

Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system.

Harold Haun, Raul Hernandez, Luzi Yan, Meghan Flanigan, Olivia Hon, Sophia Lee, Hernán Méndez, Alison Roland, Lisa Taxier, Thomas Kash

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Harold HaunBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Raul HernandezBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Morgan Community College, Fort Morgan, CO 80701, USA.
Luzi YanBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Meghan FlaniganBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Olivia HonBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Sophia LeeBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Hernán MéndezBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Alison RolandBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Lisa TaxierBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Thomas KashBowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: tkash@email.unc.edu.

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
Supplement to Molecular and Cellular Studies on Alcohol's ActionsT32AA007573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FULTON T CREWS, Thomas L. Kash · 1997 to 2026
$9.3M
Probing Ethanol Induced Acceleration of Hindbrain and Amygdalar Pathology in an Alzheimer’s Disease ModelU01AA020911 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, Zoe Anastasia McElligott · 2012 to 2026
$5.8M
The Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6M
Regulation of alcohol-induced social disturbances by lateral habenula serotonin receptorsK99AA030628 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLANIGAN, MEGHAN ELIZABETH · 2023 to 2024
$212k
Role of nociceptin-containing neurons of the lateral septum in binge-like alcohol consumptionF32AA030494 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAUN, HAROLD L · 2022 to 2023
$139k
The Role of the Retrosplenial Cortex in Heightened Fear Following Adolescent Alcohol ExposureF32AA031395 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAXIER, LISA R · 2023 to 2023
$69k
NIAAA NIH HHS F32 AA030494NIAAA NIH HHS F32 AA031395NIAAA NIH HHS K99 AA030628NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA019454NIAAA NIH HHS T32 AA007573NIAAA NIH HHS U01 AA020911
6 · The paper itself

Abstract

High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promising intervention. To better understand the contribution of the NOP system to binge drinking, we found that nociceptin-containing neurons of the lateral septum (LS

Indexed as

Alcohol DrinkingBinge DrinkingHypothalamusOpioid PeptidesAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsNociceptinNociceptin ReceptorReceptors, OpioidNociceptinNociceptin ReceptorOpioid PeptidesOprl1 protein, mouseReceptors, Opioidalcoholaversionbinge drinkingCP: Neurosciencehypothalamuslateral septumnociceptin

Identifiers

PMID40153436
PMCPMC12181985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.