Evidence map›Paper›PMID 40153307›Full record

ReviewJournal of medical microbiology2025

Sepsis

Zahraa Al-Sultani, Timothy Jj Inglis, Benjamin McFadden, Elizabeth Thomas, Mark Reynolds

Abstract readReview
In one paragraph

Review in Journal of medical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Marginal notes, June 2025. Artificial Stupidity.Journal of medical microbiology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zahraa Al-SultaniSchool of Physics, Maths and Computing, Computer Science and Software Engineering, University of Western Australia, Crawley, WA 6009, Australia.
Timothy Jj InglisDivision of Pathology and Laboratory Medicine, School of Medicine, University of Western Australia, Crawley, WA 6009, Australia.
Benjamin McFaddenSchool of Physics, Maths and Computing, Computer Science and Software Engineering, University of Western Australia, Crawley, WA 6009, Australia.
Elizabeth ThomasCurtin School of Population Health, Curtin University, Bentley, WA 6845, Australia.
Mark ReynoldsSchool of Physics, Maths and Computing, Computer Science and Software Engineering, University of Western Australia, Crawley, WA 6009, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repurposing electronic health record (EHR) or electronic medical record (EMR) data holds significant promise for evidence-based epidemic intelligence and research. Key challenges include sepsis recognition by physicians and issues with EHR and EMR data. Recent advances in data-driven techniques, alongside initiatives like the Surviving Sepsis Campaign and the Severe Sepsis and Septic Shock Management Bundle (SEP-1), have improved sepsis definition, early detection, subtype characterization, prognostication and personalized treatment. This includes identifying potential biomarkers or digital signatures to enhance diagnosis, guide therapy and optimize clinical management. Machine learning applications play a crucial role in identifying biomarkers and digital signatures associated with sepsis and its sub-phenotypes. Additionally, electronic phenotyping, leveraging EHR and EMR data, has emerged as a valuable tool for evidence-based sepsis identification and management. This review examines methods for identifying sepsis cohorts, focusing on two main approaches: utilizing health administrative data with standardized diagnostic coding via the International Classification of Diseases and integrating clinical data. This overview provides a comprehensive analysis of current cohort identification and electronic phenotyping strategies for sepsis, highlighting their potential applications and challenges. The accuracy of an electronic phenotype or signature is pivotal for precision medicine, enabling a shift from subjective clinical descriptions to data-driven insights.

Indexed as

Electronic Health RecordsSepsisBiomarkersHumansMachine LearningPhenotypeBiomarkersbloodstream infectiondigital phenotypemachine learningprecision medicinesepsis

Identifiers

PMID40153307
PMCPMC12452029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.