ArticleeLife2025
Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Nested spatiotemporal theta-gamma waves organize hierarchical processing across the mouse visual cortex.Nature communications · 2026Article
- Inter- and intrahemispheric sources of vestibular signals to V1.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025Article
- In vivo dual-plane 3-photon microscopy: spanning the depth of the mouse neocortex.Biomedical optics express · 2024Article
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Authors and funding
3 authors.
Funding
Abstract
The neocortex comprises anatomically discrete yet interconnected areas that are symmetrically located across the two hemispheres. Determining the logic of these macrocircuits is necessary for understanding high level brain function. Here in mice, we have mapped the areal and laminar organization of the ipsi- and contralateral cortical projection onto the primary visual, somatosensory, and motor cortices. We find that although the ipsilateral hemisphere is the primary source of cortical input, there is substantial contralateral symmetry regarding the relative contribution and areal identity of input. Laminar analysis of these input areas show that excitatory Layer 6 corticocortical cells (L6 CCs) are a major projection pathway within and between the two hemispheres. Analysis of the relative contribution of inputs from supra- (feedforward) and infragranular (feedback) layers reveals that contra-hemispheric projections reflect a dominant feedback organization compared to their ipsi-cortical counterpart. The magnitude of the interhemispheric difference in hierarchy was largest for sensory and motor projection areas compared to frontal, medial, or lateral brain areas due to a proportional increase in input from L6 neurons. L6 CCs therefore not only mediate long-range cortical communication but also reflect its inherent feedback organization.
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Registered trials
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