Evidence map›Paper›PMID 40153258›Full record

Trial reportAmerican journal of speech-language pathology2025

Feasibility of Endoscopic Evaluations of Laryngeal Function After Extubation for Research in Critically Ill Adults.

Vinciya Pandian, Sai Phani Sree Cherukuri, Mounica Koneru, Gowthami Sai Kogilathota Jagirdhar Reddy, Pooja Kota, Victor D Dinglas, Elizabeth Colantuoni, Lee Akst, Alexander T Hillel, Dale M Needham and 1 more

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of speech-language pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vinciya PandianCenter for Immersive Learning and Digital Innovation, Ross and Carol Nese College of Nursing, The Pennsylvania State University, University Park.ORCID 0000-0002-2260-1080
Sai Phani Sree CherukuriDepartment of Medicine, MedStar Union Memorial Hospital, Baltimore, MD.
Mounica KoneruDepartment of Pediatrics, The Brooklyn Hospital Center, NY.
Gowthami Sai Kogilathota Jagirdhar ReddyDepartment of Medicine, Saint Michael's Medical Center, Newark, NJ.
Pooja KotaNeurocardiology Research Program of Excellence, University of California, Los Angeles.
Victor D DinglasOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD.
Elizabeth ColantuoniOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD.
Lee AkstJohns Hopkins Voice Center, Towson, MD.
Alexander T HillelDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Dale M NeedhamOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD.
Martin B BrodskyOutcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-3645-2944

Funding

Symptoms Assessment and Screening for Laryngeal Injury Post-extubation in ICUR01NR017433 · NINR · JOHNS HOPKINS UNIVERSITY · PI BRODSKY, MARTIN BRUCE, NEEDHAM, DALE MURRAY · 2018 to 2022
$3.2M
NINR NIH HHS R01 NR017433
6 · The paper itself

Abstract

purposeFlexible nasal laryngoscopy (FNL) is commonly used in intensive care units (ICUs) to assess laryngeal anatomy and function after endotracheal intubation. The use of FNL in research may differ from clinical practice due to requirements of research protocols and related data collection and documentation. This study evaluates the feasibility of performing FNL post-extubation in critically ill adults within the context of a research protocol. Understanding the feasibility of this reference standard assessment is important for supporting future studies and improving patient care.

methodThis prospective study, conducted in six ICUs within a single academic medical center, consecutively enrolled adult patients who required mechanical ventilation for at least 8 hr. The primary feasibility outcome was the successful completion of FNL within 72 hr of extubation. Secondary outcomes included completion of the 3-oz water swallow test (Yale Swallow Protocol) during the FNL, patient enrollment/exclusion/withdrawal rates, time from extubation to FNL, procedure duration, and patient-reported pain (using the Wong-Baker FACES Pain Rating Scale).

resultsA total of 80 patients (75%) of 107 eligible patients fully completed FNL. Among the 24 patients who did not receive FNL, eight died, seven were medically inappropriate, and seven declined FNL. The median time from extubation to FNL was 10 hr (IQR [interquartile range]: 8-12 hr), and the median FNL procedure duration was 8.5 min (IQR: 5.8-12.9 min). The median (IQR) pain score was 2 (0, 4) of 10, reflecting only mild discomfort.

conclusionPost-extubation FNL is feasible within the context of a research protocol and well tolerated by critically ill adults.

Indexed as

Airway ExtubationCritical IllnessIntubation, IntratrachealLaryngoscopyLarynxAdultAgedFeasibility StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesRespiration, Artificial

Identifiers

PMID40153258
PMCPMC12083763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.