Evidence map›Paper›PMID 40153252›Full record

ArticleAmerican journal of speech-language pathology2025

Optimizing Detection of Very Mild Aphasia With Letter Fluency Tests.

Alycia B Laks, Andrew T DeMarco, Peter E Turkeltaub

Abstract read
In one paragraph

Article in American journal of speech-language pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Rapid Lexical Retrieval and Executive Functioning in Very Mild Aphasia.American journal of speech-language pathology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alycia B LaksDepartment of Neurology, Georgetown University Medical Center, Washington, DC.ORCID 0009-0002-3066-4249
Andrew T DeMarcoDepartment of Neurology, Georgetown University Medical Center, Washington, DC.ORCID 0000-0003-1987-2012
Peter E TurkeltaubDepartment of Neurology, Georgetown University Medical Center, Washington, DC.ORCID 0000-0003-2080-6055

Funding

Contributions of spared brain structures and connections to aphasia recoveryR01DC014960 · NIDCD · GEORGETOWN UNIVERSITY · PI TURKELTAUB, PETER ETHAN · 2017 to 2021
$4.0M
Functional anomaly mapping of aphasia recoveryR00DC018828 · NIDCD · GEORGETOWN UNIVERSITY · PI DEMARCO, ANDREW T · 2023 to 2025
$747k
NIDCD NIH HHS R00 DC018828NIDCD NIH HHS R01 DC014960
6 · The paper itself

Abstract

purposeThe purpose of this study was to find an efficient measure for clinicians to diagnose very mild aphasia.

methodTwenty-seven individuals with very mild aphasia who tested as not aphasic by the Western Aphasia Battery-Revised (WAB-R; NABW) were compared to 68 matched controls on 28 tests. Group-level differences were determined with independent-samples

resultsTwenty out of 28 behavioral tests and subtests had group-level differences, with 18 surviving Bonferroni correction. Only scores derived from letter fluency and a two-letter fluency test had sensitivity and specificity ≥ .70. The Boolean combination of letter fluency and two-letter fluency tests gave a sensitivity of .89 and specificity of .81.

conclusionsThe combined letter fluency and two-letter fluency tests were sensitive in detecting very mild aphasia beyond what is captured in the WAB-R. Administration takes an estimated 11 min, making it accessible to clinicians in various settings. While letter fluency tests rely on phonological and orthographic knowledge, they are also frequently used to measure executive control. Thus, this combined letter fluency test should be used in conjunction with other language and cognitive assessments to determine treatment targets.

Indexed as

AphasiaLanguage TestsVerbal BehaviorAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsPredictive Value of TestsROC CurveSensitivity and SpecificitySeverity of Illness Index

Identifiers

PMID40153252
PMCPMC12083766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.