ArticleJournal of assisted reproduction and genetics2025
Application of a single "Universal warming protocol" for vitrified donor oocytes: A multicenter study.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cryopreservation of Mammalian Oocytes: Slow Cooling and Vitrification Approaches.Methods in molecular biology (Clifton, N.J.) · 2026Article
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11 authors.
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Abstract
purposeThe objective of the multicenter study is to demonstrate the efficacy of the "Universal Warming Protocol (UWP)" using different devitrification media in donor oocytes that were previously vitrified in a single egg bank.
methodA total of 2172 oocytes (metaphase II) were vitrified at Ovobank (Spain) using Kitazato vitrification media (Kitazato, Japan). The oocytes were devitrified at three different centers. Group A: 1021 oocytes devitrified with Kitazato media (Kitazato, Japan); Group B: 496 oocytes devitrified with Irvine media (Fujifilm Irvine Scientific, USA); Group C: 655 oocytes devitrified with RapidWarm Omni media (Vitrolife, Sweden). The study parameters included survival rate, fertilization rate, cleavage rate, blastulation rate, and a pregnancy rate confirmed by a biochemical test; transferring embryos at D + 3 and D + 5; and clinical pregnancy rate, transferring embryos at D + 3 and D + 5.
resultsThe survival rate was statistically higher in Group C (94%) compared to Group A (86%) and Group B (85%) (P value < 0.01). There were no statistically significant differences in the remaining parameters: fertilization rate (A: 77%, B: 74%, C: 73%); cleavage rate (A: 83%, B: 83%, C: 80%); blastulation rate (A: 52%, B: 58%, C: 57%); a pregnancy rate confirmed by a biochemical test in transferring embryos at D + 3 (A: 38%, B: 33%, C: 33%); a pregnancy rate confirmed by a biochemical test in transferring embryos at D + 5 (A: 54%, B: 76%, C: 65%); clinical pregnancy rate in transferring embryos at D + 3 (A: 27%, B: 13%, C: 18%); clinical pregnancy rate in transferring embryos at D + 5 (A: 39%, B: 57%, C: 60%).
conclusionsThe idea that oocyte devitrification medium should always be from the same supplier is questionable. Therefore, it is feasible to use different devitrification media for donor oocytes that were vitrified with the same vitrification medium.
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