ArticleAMB Express2025
Anti-virulence effect of photoactivated nano-quercetin by diode laser on Aggregatibacter actinomycetemcomitans.
Article in AMB Express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Experimental and theoretical investigation of the antimicrobial effect of femtosecond laser irradiation on contact lens solutions.Archives of microbiology · 2026Article
- Development and in vitro evaluation of a xylitol/erythritol carbomer gel for xerostomia relief.Odontology · 2026Article
- Enhancing Caries Preventive Effects of Nanomaterials with Phototherapy: A Scoping Review.Journal of functional biomaterials · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT) is an innovative, non-invasive, and selective treatment approach that has gained attention as an adjunctive treatment in periodontitis. Aggregatibacter actinomycetemcomitans is an opportunistic periodontopathogen known for its ability to form biofilms. The objective of this in vitro study was to determine the anti-virulence effect of nano-quercetin (N-QT)-mediated PDT on the expression of a gene associated with biofilm formation of A. actinomycetemcomitans. After synthesis and characterization of N-QT by transmission electron microscopes (TEM), dynamic light scattering (DLS), zeta potential analysis, and fourier transform infrared spectroscopy (FTIR) analysis, the effects of different concentrations of N-QT and energy densities of diode laser alone on cell viability of A. actinomycetemcomitans were evaluated. A. actinomycetemcomitans was then treated by sub-lethal doses of diode laser emitting light in the presence of sub-lethal doses of N-QT. Ultimately, the sub-lethal dose of PDT was used to investigate the metabolic activity of A. actinomycetemcomitans, the generation of reactive oxygen species (ROS), and changes in rcpA, qseB, and qseC genes expression using the quantitative real-time polymerase chain reaction (qRT-PCR) method. According to the results, TEM, DLS, zeta potential, and FTIR confirmed the synthesis of N-QT. PDT with concentrations of 16 to 512 µg/mL of N-QT alone and irradiation for 6 min with an energy density of 154.8 J/cm
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