Evidence map›Paper›PMID 40153159›Full record

ArticleBulletin of experimental biology and medicine2025

Redox-Regulated Cell Response Mechanisms to Nitrosyl Iron Complex with N-Ethylthiourea in Human Mesenchymal Stem Cells In Vitro.

A A Balakina, V I Amozova, T S Stupina, N A Sanina

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A A BalakinaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. balakina@icp.ac.ru.
V I AmozovaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
T S StupinaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
N A SaninaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the processes of cell death and intracellular accumulation of free radicals, as well as activity of redox-sensitive transcription factors Nrf2 and NF-κB under the action of nitrosyl iron complex with N-ethylthiourea (ETU) on a model of human mesenchymal stem cells in vitro. ETU complex exhibits a pronounced prooxidant and cytotoxic effects accompanied by enhanced intracellular accumulation of nitrogen monoxide, induction of apoptotic cell death, activation of Nrf2/HO-1 pathways, and suppression of proinflammatory NF-κB-mediated reactions. A significant role of redox-dependent cellular processes in the mechanisms of the cytotoxic effect of nitrosyl iron complexes is shown.

Indexed as

IronMesenchymal Stem CellsThioureaApoptosisCells, CulturedHeme Oxygenase-1HumansNF-E2-Related Factor 2NF-kappa BNitric OxideNitrogen OxidesOxidation-ReductionReactive Oxygen Speciesdinitrosyl iron complexHeme Oxygenase-1HMOX1 protein, humanIronNFE2L2 protein, humanNF-E2-Related Factor 2NF-kappa BNitric OxideNitrogen OxidesReactive Oxygen SpeciesThioureaNF-κBnitrogen monoxidenitrosyl iron complexesNrf2reactive oxygen species

Identifiers

PMID40153159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.