Evidence map›Paper›PMID 40153100›Full record

ReviewMetabolic brain disease2025

The beneficial effects of D-allose and D-allulose on the brain under ischemic stroke and obese-insulin resistant conditions: evidence from in vitro to clinical studies.

Yanmei Huang, Chanisa Thonusin, Masaaki Tokuda, Nipon Chattipakorn, Siriporn C Chattipakorn

Abstract readReview
PubMed Publisher
In one paragraph

Review in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yanmei HuangDepartment of Ultrasonography, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China.
Chanisa ThonusinNeurophysiology Unit, Cardiac Electrophysiology Research and Training Centre, Faculty of Medicine, Chiang Mai University, Chiang Mai, Chiang Mai, 50200, Thailand.
Masaaki TokudaDepartment of Cellular Physiology, Faculty of Medicine, Kagawa University, Kagawa, 761- 0793, Japan.
Nipon ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Centre, Faculty of Medicine, Chiang Mai University, Chiang Mai, Chiang Mai, 50200, Thailand.
Siriporn C ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Centre, Faculty of Medicine, Chiang Mai University, Chiang Mai, Chiang Mai, 50200, Thailand. scchattipakorn@gmail.com.

Funding

Chiang Mai University CMU excellent center awardChiang Mai University Visiting Professor GrantNational Research Council of Thailand N42A660301National Research Council of Thailand N42A670594
6 · The paper itself

Abstract

Ischemic stroke, and obese-insulin resistance are common pathological conditions that lead to brain injury, resulting in neurodegeneration, brain atrophy, and cognitive dysfunction. Rare sugars, which are scarce monosaccharide in nature, have been investigated as a potential treatment for these adverse conditions. However, the beneficial effects of rare sugars on the brain have never been summarized. Therefore, this article comprehensively summarizes and discusses the benefits of rare sugars on the brain under physiological condition, ischemic stroke, and obese-insulin resistance. The potential mechanisms mediating these benefits of rare sugars are also described. Any contradictory findings are also included. This article adds weight to the impetus for further investigations into the applications of rare sugars as a novel therapeutic paradigm in clinical application.

Indexed as

BrainFructoseGlucoseInsulin ResistanceIschemic StrokeObesityAnimalsHumansalloseFructoseGlucoseBrainIschemic strokeObesity and insulin resistanceRare sugars

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.