Evidence map›Paper›PMID 40153047›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Unveiling the role of miRNA in laryngeal squamous cell carcinoma progression: a retrospective study.

Nejmiye Akkuş, Elif Kaya Çelik, Suleyman Ozdemir, Emrah Sapmaz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nejmiye AkkuşFaculty of Medicine, Department of Medical Genetics, Tokat Gaziosmanpasa University, Tokat, Turkey.ORCID http://orcid.org/0000-0002-5801-534X
Elif Kaya ÇelikFaculty of Medicine, Department of Otolaryngology Head and Neck Surgery, Tokat Gaziosmanpasa University, Tokat, Turkey. elifkayacelikdr@gmail.com.ORCID http://orcid.org/0000-0003-2050-441X
Suleyman OzdemirFaculty of Medicine, Department of Pathology, Tokat Gaziosmanpasa University, Tokat, Turkey.ORCID http://orcid.org/0000-0001-8202-9955
Emrah SapmazFaculty of Medicine, Department of Otolaryngology Head and Neck Surgery, Tokat Gaziosmanpasa University, Tokat, Turkey.ORCID http://orcid.org/0000-0002-0346-8704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMicroRNAs (miRNAs) have emerged as promising biomarkers for diagnosis and prognosis in laryngeal squamous cell carcinoma (LSCC). This study investigates the expression patterns of specific cancer-associated miRNAs in early and advanced stage LSCC to evaluate their potential role in disease progression.

methodsThe expression levels of miRNA-21, miRNA-802, miRNA-29 and miRNA-9 were analysed in formalin-fixed paraffin-embedded (FFPE) tissues from 44 LSCC patients (20 early stage, 24 advanced stage) using quantitative multiplex RT-PCR. Tissue samples were analysed retrospectively.

resultsThe expression level of hsa-miR-9a expression was significantly upregulated (5.2-fold) in advanced stage patients compared to the early stage group (p = 0.0088). Similarly, hsa-miR-802a showed significantly higher expression (9.2-fold) in advanced stage patients compared to early stage patients (p = 0.005). No significant differences in miRNA-21 and miRNA-29 expression levels were observed between the groups.

conclusionAs a result of the study, elevated miRNA levels in advanced stage patients can be used in targeted therapy and evaluated as a treatment option in LSCC patients.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsMicroRNAsAdultAgedBiomarkers, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanMIRN29a microRNA, humanMIRN92 microRNA, humanLSCCmiRNA-21miRNA-29miRNA-802miRNA-9

Identifiers

PMID40153047
PMCPMC12321904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.