ArticleEuropean child & adolescent psychiatry2025
Prefrontal-hippocampal pathways underlying adolescent resilience.
Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of MRI-based gray matter volume (GMV) to map connectivity networks centered on the hippocampus, investigating whether structural similarity between prefrontal regions and hippocampus were related to resilience in a cohort of 145 adolescents. Additionally, spatial correlation analyses of resilience-related structural similarity network and neurotransmitter distribution maps were conducted to identify molecular adaptations within prefrontal-hippocampal circuits associated with resilience. The results showed that higher resilience levels were correlated with stronger structural similarity between the prefrontal areas (i.e., middle frontal gyrus and orbitofrontal cortex) and hippocampus. Furthermore, the serotonergic neurotransmitter system, which modulates neural oscillations in prefrontal-hippocampal pathways, appears to be associated with resilience. The current findings suggest that structural and molecular adaptations within prefrontal-hippocampal circuits, which are implicated in the suppression of intrusive, unwanted memories, may foster resilience in young people. These insights advance our knowledge of the neurobiological markers of resilience, paving the way for more targeted and effective therapeutic interventions to bolster resilience and mitigate adverse outcomes in developmental populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.