Evidence map›Paper›PMID 40152986›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Nocturnal diastolic hypotension is associated with central visual field defect in early and moderate normal tension glaucoma.

Sung Il Im, Changmin Cha, Sangjoon Lee, Seunguk Lee

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structure-function relationships of circumpapillary choroidal thickness in normal-tension glaucoma with and without high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sung Il ImDivision of Cardiology, Department of Internal Medicine, College of Medicine, Kosin University, Busan, Korea.ORCID http://orcid.org/0000-0003-2544-2422
Changmin ChaDepartment of Ophthalmology, College of Medicine, Kosin University, Busan, Korea.
Sangjoon LeeDepartment of Ophthalmology, College of Medicine, Kosin University, Busan, Korea.
Seunguk LeeDepartment of Ophthalmology, College of Medicine, Kosin University, Busan, Korea. seunguk28@gmail.com.ORCID http://orcid.org/0000-0001-8109-6160

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the association between systemic blood pressure-related hemodynamic indices and central-most visual field defect (CMVFD) in patients with early and moderate normal tension glaucoma (NTG).

methodsThis cross-sectional study examined 36 eyes of 36 early and moderate NTG patients with CMVFD from 295 consecutive NTG patients who underwent 24-h ambulatory blood pressure monitoring (ABPM). Hemodynamic variables and ocular examination results were compared between two groups. CMVFD was defined as a glaucomatous defect with at least one abnormal point at P < 1% within the central 5 degrees on two consecutive 24-2 or 30-2 visual field tests.

resultsThere were no significant differences in baseline demographics except for body weight (P = .009). The cup-to-disc ratio, pattern standard deviation in visual field test, and inferotemporal segmental thickness of retinal nerve fiber layer in OCT showed significant differences in the ophthalmic examinations. Univariate logistic regression analysis revealed significant association between CMVFD and 24-h average diastolic blood pressure, nighttime average systolic blood pressure, nighttime average diastolic blood pressure, and body weight. In multivariate logistic regression analysis, only the nighttime average diastolic blood pressure (odds ratio [OR] 0.877; P = .037) was independently associated with CMVFD in early and moderate NTG.

conclusionCentral-most visual field defects were identified in some patients with early and moderate NTG. Particularly, low nocturnal diastolic blood pressure (nocturnal diastolic hypotension) was independently related to CMVFD, and should be considered when managing systemic care for NTG patients. KEY MESSAGES: What is known: • The visual field defects are at greater risk in glaucoma patients with nocturnal hypotension. WHAT IS NEW: • The nocturnal diastolic hypotension is independently related to the presence of central-most visual field defect (CMVFD) in patients with early and moderate normal tension glaucoma. • If average nocturnal diastolic blood pressure is found to be low, it should be considered a modifiable risk factor for CMVFD.

Indexed as

Blood PressureCircadian RhythmHypotensionIntraocular PressureLow Tension GlaucomaVisual FieldsAgedBlood Pressure Monitoring, AmbulatoryCross-Sectional StudiesDiastoleFemaleFollow-Up StudiesHumansMaleMiddle AgedRetinal Ganglion CellsCentral-most visual field defectCentral visual fieldLow diastolic blood pressure at nightNocturnal diastolic hypotensionNormal tension glaucoma

Identifiers

PMID40152986

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.