ArticleKidney3602025
Activin A Antagonism with Follistatin Reduces Kidney Fibrosis, Injury, and Cellular Senescence-Associated Inflammation in Murine Diabetic Kidney Disease.
Abstract read
In one paragraph
Article in Kidney360, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Integrated Liver Multi-Omics Reveals Beneficial Effects and Potential Mechanisms of Noni Fruit Flavonoids on Antioxidant Status and Anti-Inflammatory Responses in Cashmere Goats.Antioxidants (Basel, Switzerland) · 2026Article
- Multi-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy.NPJ Regenerative medicine · 2026Article
- Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approaches.Kidney international · 2026Review
- Higher serum follistatin levels are associated with increased vascular calcification in haemodialysis patients.Frontiers in endocrinology · 2026Article
- Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney.Frontiers in molecular biosciences · 2026Article
- Targeting panoptosis: a narrative review of its therapeutic potential in kidney disease.BMC nephrology · 2025Review
- Inhibition of Activin A Signaling by Follistatin Alleviates Diabetic Kidney Disease Burden.Kidney360 · 2025Article
- Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Xiaohui BianDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0008-1952-0141
Zachary K SnowDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0006-6407-3390
Caroline J ZinnDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-9099-172
Cody C GowanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0007-0829-0187
Sabena M ConleyDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.
Anastasia L BratulinDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0001-9263-0891
Khaled M ElhusseinyDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-2230-2160
Jordan MillerDepartment of Surgery, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9868-4097
Tamar TchkoniaDivision of Endocrinology and Metabolism, Department of Medicine, Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California.
James L KirklandDivision of Endocrinology and Metabolism, Department of Medicine, Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California.ORCID 0000-0003-1676-4905
Lilach O LermanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-3271-3887
LaTonya J HicksonDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-7485-336
Funding
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4MCoordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6MEffect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6MEffect of Aging on Preadipocyte DifferentiationR01AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 1997 to 2012
$3.7MKIDNEY DISEASES RESEARCH TRAINING PROGRAMT32DK007013 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 1986 to 2023
$3.7MObesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · NHLBI · MAYO CLINIC ROCHESTER · PI Alfonso Eirin, Lilach O Lerman · 2022 to 2026
$3.4MObesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6MExtracellular vesicle-based senotherapeutics for aging diabetic kidneydiseaseR01AG076537 · NIA · MAYO CLINIC JACKSONVILLE · PI LaTonya J Hickson · 2023 to 2026
$2.3MMayo Clinic Summer Undergraduate Research in Nephrology & UrologyR25DK101405 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL F. ROMERO · 2014 to 2026
$1.6MMesenchymal stem cell senescence in diabetic nephropathy (K23 COVID Admin Supplement)K23DK109134 · NIDDK · MAYO CLINIC ROCHESTER · PI HICKSON, LATONYA J · 2016 to 2021
$1.0MHypoxic preconditioning for the improvement of the regenerative capacity of adipose-derived mesenchymal stem cells and its application in chronic kidney disease due to hypertensive nephropathyK08DK118120 · NIDDK · MAYO CLINIC ROCHESTER · PI HERRMANN, SANDRA M · 2018 to 2022
$800kRenal repair effects of senolytic preconditioned mesenchymal stromal PP #o20-111cells in diabetic kidney diseaseR03DK123492 · NIDDK · MAYO CLINIC ROCHESTER · PI HICKSON, LATONYA J · 2020 to 2021
$467kNHLBI NIH HHS R01 HL158691NIA NIH HHS AG076537NIA NIH HHS R01 AG013925NIA NIH HHS R01 AG076537NIA NIH HHS R37 AG013925NIDDK NIH HHS DK076169NIDDK NIH HHS DK115255NIDDK NIH HHS K08 DK118120NIDDK NIH HHS K23 DK109134NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R03 DK123492NIDDK NIH HHS R25 DK101405NIDDK NIH HHS T32 DK007013NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255NIH HHS AG076537NIH HHS DK07013NIH HHS DK101405NIH HHS DK109134NIH HHS DK118120NIH HHS DK120292NIH HHS DK123492NIH HHS HL158691NIH HHS NIH AG013925Regenerative Medicine Minnesota RMM 091718CT
Abstract
PubMed holds no abstract for this paper.
Indexed as
chronic inflammationdiabetic nephropathyfibronectinlymphocytesmacrophagespodocyterenal fibrosisrenal protectionrenal proximal tubule cell
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.