Evidence map›Paper›PMID 40152679›Full record

ArticleJournal of natural products2025

Development of a Proton Spin Network Fingerprint Library to Support Mass Spectrometry-Based Identification of Pharmacophore-Bearing Constituents in the Botanical Supplement

Sara Neiheisel, Dmitriy Uchenik, Luke Marney, Claudia S Maier, Nora E Gray, Amala Soumyanath, Harinantenaina L Rakotondraibe

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara NeiheiselDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Dmitriy UchenikCollege of Pharmacy Shared Instrumentation Facility, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0009-0005-7929-4658
Luke MarneyDepartment of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.
Claudia S MaierDepartment of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States.
Nora E GrayBENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, Oregon 97239, United States.
Amala SoumyanathBENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, Oregon 97239, United States.ORCID 0000-0003-1569-6453
Harinantenaina L RakotondraibeDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-2166-4992

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Mechanisms underlying the cognitive effects of Centella asiatica water extract and constituent compounds in the 5xFAD mouse model of Alzheimer's DiseaseU19AT010829 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SOUMYANATH, AMALA · 2020 to 2024
$6.1M
Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484k
DEVELOPMENT OF AN IN-HOUSE PROTON SPIN NETWORK DATABASE TO CHARACTERIZE THE PHARMACOPHORES OF CENTELLA ASIATICA FOR STANDARDIZATION AND QUALITY CONTROLR03AT011872 · NCCIH · OHIO STATE UNIVERSITY · PI RAKOTONDRAIBE, LIVA HARINANTENAINA · 2022 to 2023
$158k
NCCIH NIH HHS R03 AT011872NCCIH NIH HHS U19 AT010829NCRR NIH HHS S10 RR027878NIA NIH HHS P30 AG066518
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CentellaQuinic AcidTriterpenesChromatography, LiquidDietary SupplementsMass SpectrometryMolecular StructurePharmacophorecaffeoylquinic acidQuinic AcidTriterpenes

Identifiers

PMID40152679
PMCPMC12060121

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.