Evidence map›Paper›PMID 40152675›Full record

ArticleACS applied bio materials2025

Immobilization of KR-12 on a Titanium Alloy Surface Using Linking Arms Improves Antimicrobial Activity and Supports Osteoblast Cytocompatibility.

Mohadeseh Zare, Laura Colomina Alfaro, Antonella Bandiera, Esra Cansever Mutlu, David Grossin, Fernando Albericio, Sarah A Kuehne, Zubair Ahmed, Artemis Stamboulis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohadeseh ZareBiomaterials Research Group, School of Metallurgy and Materials, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Laura Colomina AlfaroDepartment of Life Sciences, University of Trieste, via L. Giorgieri 1, Trieste 34127, Italy.
Antonella BandieraDepartment of Life Sciences, University of Trieste, via L. Giorgieri 1, Trieste 34127, Italy.ORCID 0000-0002-0376-9291
Esra Cansever MutluBiomaterials Research Group, School of Metallurgy and Materials, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
David GrossinCIRIMAT, Toulouse INP, Université Toulouse 3 Paul Sabatier, CNRS, Université de Toulouse, 4 Allée Emile Monso, BP44362, 31030 Toulouse, Cedex 4, France.
Fernando AlbericioSchool of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000, South Africa.ORCID 0000-0002-8946-0462
Sarah A KuehneSchool of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, U.K.
Zubair AhmedNeuroscience and Ophthalmology, Department of Inflammation and Ageing, School of Infection, Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Artemis StamboulisBiomaterials Research Group, School of Metallurgy and Materials, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID 0000-0002-8366-590X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections pose significant challenges due to bacterial resistance to antibiotics. Recent research highlights the potential of immobilizing antimicrobial peptides (AMPs) onto implants as an alternative to conventional antibiotics for the prevention of bacterial infection. While various AMP immobilization methodologies have been investigated, they lack responsiveness to biological cues. This study proposes an enzyme-responsive antimicrobial coating for orthopedic devices using KR-12, an AMP derived from Cathelicidin LL-37, coupled with the Human Elastin-Like Polypeptide (HELP) as a biomimetic and stimuli-responsive linker, while mimicking the extracellular matrix (ECM). During implantation, these customized interfaces encounter the innate immune response triggering elastase release, which degrades HELP biopolymers, enabling the controlled release of KR-12. After coupling KR-12 with HELP to titanium surfaces, the antimicrobial activity against four pathogenic bacterial strains (

Indexed as

AlloysAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiocompatible MaterialsCoated Materials, BiocompatibleOsteoblastsTitaniumBacterial AdhesionEscherichia coliHumansMaterials TestingMicrobial Sensitivity TestsParticle SizePseudomonas aeruginosaStaphylococcus aureusStaphylococcus epidermidisAlloysAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiocompatible MaterialsCoated Materials, BiocompatibleTitaniumantimicrobial peptidebacterial growth inhibitionenzyme-responsive coatingHuman-Elastin Like PolypeptideKR-12osteoblast promotion

Identifiers

PMID40152675
PMCPMC12015957

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.