Evidence map›Paper›PMID 40152540›Full record

ArticleJournal of medicinal chemistry2025

Ecdysteroid-Containing Squalenoylated Self-Assembling Nanoparticles Exert Tumor-Selective Sensitization to Reactive Oxygen Species (ROS)-Induced Oxidative Damage While Protecting Normal Cells: Implications for Selective Radiotherapy.

Máté Vágvölgyi, Endre Kocsis, Bizhar A Tayeb, István Zupkó, Renáta Minorics, Ana Martins, Zsófia Hoyk, Gergő Ballai, Imre Szenti, Zoltán Kónya and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Máté VágvölgyiInstitute of Pharmacognosy, University of Szeged, Eötvös str. 6, Szeged H-6720, Hungary.
Endre KocsisInstitute of Pharmacognosy, University of Szeged, Eötvös str. 6, Szeged H-6720, Hungary.
Bizhar A TayebInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös str. 6, Szeged H-6720, Hungary.
István ZupkóInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös str. 6, Szeged H-6720, Hungary.
Renáta MinoricsInstitute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös str. 6, Szeged H-6720, Hungary.ORCID 0000-0001-9685-813X
Ana MartinsInstitute of Biophysics, HUN-REN Biological Research Centre, Temesvári blvd. 62, Szeged H-6726, Hungary.
Zsófia HoykInstitute of Biophysics, HUN-REN Biological Research Centre, Temesvári blvd. 62, Szeged H-6726, Hungary.
Gergő BallaiDepartment of Applied and Environmental Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Rerrich Béla sq. 1, Szeged H-6720, Hungary.
Imre SzentiDepartment of Applied and Environmental Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Rerrich Béla sq. 1, Szeged H-6720, Hungary.
Zoltán KónyaDepartment of Applied and Environmental Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Rerrich Béla sq. 1, Szeged H-6720, Hungary.ORCID 0000-0002-9406-8596
Tamás GátiServier Research Institute of Medicinal Chemistry (SRIMC), Záhony str. 7, Budapest H-1031, Hungary.
Dóra BogdánDepartment of Organic Chemistry, Semmelweis University, Hőgyes Endre str. 7, Budapest H-1092, Hungary.
Gábor TóthNMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért sq. 4, Budapest H-1111, Hungary.
Attila HunyadiInstitute of Pharmacognosy, University of Szeged, Eötvös str. 6, Szeged H-6720, Hungary.ORCID 0000-0003-0074-3472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous system (CNS) tumors are exceptionally difficult to treat, and oxidative stress-inducing radiotherapy is an important treatment modality. In this study, we examined self-assembling pro-drug nanoconjugates of naturally derived antitumor ecdysteroids, which were designed to interfere with oxidative stress in brain tumor cells. Eight ecdysteroid-squalene conjugates were semi-synthesized and formulated into self-assembled aqueous nanosuspensions, which showed excellent stability for up to 16 weeks. The nanoassemblies demonstrated a strong dose-dependent sensitizing effect to

Indexed as

Antineoplastic AgentsEcdysteroidsNanoparticlesOxidative StressReactive Oxygen SpeciesSqualeneBrain NeoplasmsCell Line, TumorHumanstert-ButylhydroperoxideAntineoplastic AgentsEcdysteroidsReactive Oxygen SpeciesSqualenetert-Butylhydroperoxide

Identifiers

PMID40152540
PMCPMC11997992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.