ArticleJournal of clinical laboratory analysis2025
Predictive Effect of FT3 Within the Euthyroid Range on HDL-C in Patients With Type 2 Diabetes: A Cross-Sectional Analysis of Inpatients in China.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEvidence for assessing the relationship between free triiodothyronine (FT3) and high-density lipoprotein cholesterol (HDL-C) remains limited. Therefore, the purpose of our study is to evaluate the relationship between FT3 and HDL-C in patients with type 2 diabetes.
methodsFrom June 2022 to October 2023, 3011 patients with normal thyroid function and diagnosed with type 2 diabetes mellitus (T2DM) were collected continuously and non-selectively in a Chinese hospital. Then, we used a logistic regression model to explore the relationship between FT3 and HDL-C. Smooth curve fitting is used to identify the nonlinear relationship between FT3 and HDL-C.
resultsAfter adjusting for the influence of relevant factors, FT3 and HDL-C were negatively correlated -0.02 (-0.04, -0.00; p = 0.0162). There is also a nonlinear relationship between FT3 and HDL-C, with an inflection point of 3.48 pmol/L for FT3 (P for log- likelihood ratio test = 0.044).
conclusionThis study shows that there is a negative correlation and nonlinear relationship between FT3 and HDL-C in the Chinese population with diabetes. When FT3 is between 2.76-3.48 pmol/L, HDL-C tends to a stable state; When FT3 is between 3.48-6.45 pmol/L, HDL-C decreases with the increase of FT3 concentration (According to the reference range used by our hospital, the normal value of serum FT3 is 2.76-6.45 pmol/L). These findings suggest that maintaining FT3 within the range of 2.76 to 3.48 pmol/L may be most beneficial for mitigating the progression of cardiovascular disease in patients with T2DM.
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