Evidence map›Paper›PMID 40152138›Full record

SynthesisJournal of clinical ultrasound : JCU2025

Prenatal Diagnosis and Prognostic Factors in Fetuses With Arthrogryposis Multiplex Congenita-A Systematic Review.

Mario Brock Leao, Marianna Facchinetti Brock, Jorge Roberto Di Tommaso Leao, Gianpaolo Grisolia, Mario Lituania, Samantha Erin Neumann, Gabriele Tonni, Rodrigo Ruano

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical ultrasound : JCU, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Management of Lower-Extremity Deformity in Arthrogryposis Multiplex Congentia: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mario Brock LeaoUniversity of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-5924-8463
Marianna Facchinetti BrockUniversity of the Amazon State, Manaus, Brazil.ORCID https://orcid.org/0000-0002-9356-116X
Jorge Roberto Di Tommaso LeaoUniversity of the Amazon State, Manaus, Brazil.ORCID https://orcid.org/0000-0001-7701-6834
Gianpaolo GrisoliaDepartment of Obstetrics and Gynecology, Carlo Poma Hospital, AST Mantova, Mantova, Italy.ORCID https://orcid.org/0000-0001-5314-7231
Mario LituaniaPreconceptional and Prenatal Pathophysiology, Department of Obstetrics and Gynecology, E.O. Ospedali Galliera, Genoa, Italy.ORCID https://orcid.org/0009-0006-5436-0185
Samantha Erin NeumannDepartment of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.ORCID https://orcid.org/0009-0007-5113-1763
Gabriele TonniPrenatal Diagnostic Centre, Department of Obstetrics and Neonatology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), AUSL, Reggio Emilia, Italy.ORCID https://orcid.org/0000-0002-2620-7486
Rodrigo RuanoDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Miami, Miller School of Medicine, Miami, Florida, USA.ORCID https://orcid.org/0000-0002-3642-5858

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arthrogryposis Multiplex Congenita (AMC) is characterized by the presence of multiple joint contractures in the fetus' body. The diagnosis of AMC is complex and often missed prenatally. This comprehensive review of the literature published over the last 20 years, with an emphasis on the role of prenatal ultrasound in predicting postnatal outcomes in a fetus with AMC, showed that ultrasound is a crucial tool to diagnose and prognosticate this rare disease. Different clinical manifestations of AMC are associated with different outcomes. Postnatal prognosis depends on several factors. Future multicenter prospective studies are necessary to investigate the prognostic factors associated with AMC.

Indexed as

ArthrogryposisUltrasonography, PrenatalFemaleHumansPregnancyPrognosisarthrogryposis multiplex congenitaoutcomesprenatal imagingprognosisultrasound

Identifiers

PMID40152138
PMCPMC12172144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.