Evidence map›Paper›PMID 40151893›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Neural Plasticity and Hearing-Speech Development in Children with Auditory Brainstem Implants for Congenital Hearing Loss Due to Severe Inner Ear Malformation.

Yu Zhang, Yongchuan Chai, Yiwen Zhang, Huan Jia, Zhaoyan Wang, Zhihua Zhang, Zhili Wang, Jie Chen, Xue Wang, Yun Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Neural response patterns in inner ear malformations: a scoping review of eABR findings.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu ZhangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Yongchuan ChaiDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Yiwen ZhangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Huan JiaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Zhaoyan WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Zhihua ZhangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Zhili WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Jie ChenDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Xue WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Yun LiDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Ying ChenDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.
Hao WuDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, China.ORCID https://orcid.org/0000-0002-5317-902X

Funding

Clinical Research Project of Shanghai Municipal Health Commission 202240003Natural Science Foundation of China 82371141Natural Science Foundation of Shanghai 23ZR1437100Shanghai Auditory and Otoneurological Surgery Center 2023ZZ02008Shanghai Jiaotong University School of Medicine NO.2022LHA03Shanghai Ninth People's Hospital ClinicalSpecialty-OtorhinolaryngologyShanghai Ninth People's Hospital Excellent-Clinical-Research-PhysicianShanghai Ninth People's Hospital YBKA202205Shanghai Shenkang Hospital Development Center SHDC12020105
6 · The paper itself

Abstract

Hearing and speech outcomes of pediatric patients with auditory brainstem implants (ABI) are variable, and the underlying developmental mechanism remains unexplored. This study aims to evaluate the effectiveness of ABI in pediatric patients with congenital non-tumor hearing loss and elucidate the role of cortical plasticity in hearing and speech development. A prospective cohort study is conducted involving 112 consecutive pediatric patients who received ABI at a tertiary university-based referral center from January 2019 to October 2023. The mean age at the time of surgery and postoperative follow-up are 3.4±1.9 years and 25.7±11.7 months (3-48 months), respectively. The average percentage of elicited electrodes (eABR%) during the operation is 72.73±17.99%. Post-activation, hearing and speech outcomes improved steadily. Younger age at implantation (<3 years), less severe inner-ear malformation, and higher intraoperative eABR% (≥60%) are significantly associated with better hearing and speech outcomes. Mismatch negativity (MMN) responses are evoked in all children aged 12-18 months. Cortical functional connectivity developed after activation, particularly within the bilateral temporal/frontal lobes. Several factors contribute to hearing and speech development in children with ABI, and cortical plasticity plays a pivotal role. MMN amplitude and brain functional connectivity may serve as cortical indices for predicting long-term outcomes.

Indexed as

Auditory Brain Stem ImplantationAuditory Brain Stem ImplantsEar, InnerHearing LossNeuronal PlasticityChildChild, PreschoolFemaleHumansInfantMaleProspective Studiesauditory brainstem implantelectroencephalogramfunctional near‐infrared spectroscopyneural plasticity

Identifiers

PMID40151893
PMCPMC12362790

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.