ArticleChemical & biomedical imaging2025
Long-Term Real-Time Tracking of Morphology and Migration of Neuronal Cells under Oxidative Stress.
Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Dynamic Contour Evolution Algorithm for Cell Segmentation and Synaptic Tracking under Occlusion.Chemical & biomedical imaging · 2026Article
- Aquaporin 5 expression regulates MDA-MB-231 spheroid multicellular invasion.American journal of physiology. Cell physiology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal cells exhibit diverse morphologies that are crucial for their function within the neuronal network. Long-term quantitative analysis of both neuronal cell morphology and migration is essential in neuroscience research but remains challenging. Sodium arsenite, a known inducer of oxidative stress in neurons, affects both cell morphology and migration. To rapidly assess oxidative stress in HT22 neuronal cells, we developed a method for tracking key morphological features and migration trajectories of the individual cells. Three time-dependent parameters-velocity, circularity increment, and turn angle-are identified as rapid, direct indicators of the early stages of oxidative stress in neuronal cells. This method is then applied to investigate the effects of arsenite exposure on neuronal cells. Our approach provides a valuable tool for the rapid, label-free, and long-term real-time tracking of oxidative stress in neuronal cells, offering potential insights into cellular responses under stress conditions.
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Registered trials
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