ArticleJCSM communications
A Dynamic Time Warping Extension to Consensus Weight-Based Cachexia Criteria Improves Prediction of Cancer Patient Outcomes.
Article in JCSM communications. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Does Cachexia Matter for Glioblastoma Multiforme?Cancers · 2026Article
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13 authors.
Funding
Abstract
Background: Cachexia is a complex syndrome that impacts up to half of patients with cancer. Criteria systems have been developed for the purpose of diagnosing and grading cachexia severity in clinical settings. One of the most widely known is those developed by Fearon et al. in 2011, which utilizes body mass loss and body mass index (BMI) to determine the presence and extent of cachexia. One limitation of this system and other clinical cachexia scales is the lack of systematic methods for assessing cachexia severity longitudinally. We sought to develop an extension to the 2011 consensus criteria that categorizes cancer patients with respect to their temporal cachexia progression and assess its predictive capacity relative to the current time-agnostic system. Methods: Two cancer cohorts were identified in electronic health record data: lung cancer and glioblastoma. We extracted weight and BMI measures from the time of cancer diagnosis until death or loss to follow-up and computed cachexia severity according to the consensus criteria. Subgroups of cachexia progression were uncovered using dynamic time warping (DTW) followed by unsupervised clustering. This system and baseline consensus criteria measurements were each assessed for their ability to stratify patient outcomes utilizing Kaplan-Meier curves and Cox proportional hazards and subsequently compared with model concordance and inverse probability of censoring weighting (IPCW). Results: Significant differences were observed in overall survival Kaplan-Meier curves of 1023 patients with lung cancer when stratified by baseline cachexia classification ( Conclusions: Our results suggest that accounting for cachexia's longitudinal progression in a systematic way can improve upon the prognostic capacity of a widely used consensus criteria set. These findings are important for the future development of systems that recognize concerning patterns of cachexia progression in clinical settings and aid clinicians in cachexia-related decision making.
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