Evidence map›Paper›PMID 40151801›Full record

ArticleFrontiers in oncology2025

Mapping MAGE-A4 expression in solid cancers for targeted therapies.

Christin Habigt, Sylvie Rottey, Iben Spanggaard, Juanita S Lopez, Elena Garralda, Emiliano Calvo, Oliver Bechter, Jayesh Desai, Rachel Galot, Leena Gandhi and 7 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christin HabigtRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Munich, Penzberg, Germany.
Sylvie RotteyDepartment of Medical Oncology, UZ Gent, Ghent, Belgium.
Iben SpanggaardDepartment of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Juanita S LopezPhase I Drug Development Unit, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
Elena GarraldaInstitute of Oncology (VHIO), Vall d'Hebron University Hospital, Barcelona, Spain.
Emiliano CalvoSTART Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain.
Oliver BechterDepartment of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.
Jayesh DesaiPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Rachel GalotUniversité Catholique de Louvain and Institut Roi Albert II, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Leena GandhiEarly Drug Development Center, Dana-Farber Cancer Institute, Boston, MA, United States.
Florian HeilRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Munich, Penzberg, Germany.
Natascha RiederRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Munich, Penzberg, Germany.
Ivan DimitrovCDx Pharma Services Assay Development, Roche Tissue Diagnostics, Tucson, AZ, United States.
Iris Martinez QuetglasRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Zurich, Zurich, Switzerland.
Christian HeichingerRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Basel, Basel, Switzerland.
Nino KeshelavaRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Zurich, Zurich, Switzerland.
Andreas RollerRoche Pharma Research and Early Development, Early Development Oncology, Roche Innovation Center Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma-associated antigen A4 (MAGE-A4) is a promising target for anticancer therapy. However, limited contemporary data are available on the details of MAGE-A4 protein expression in different cancer types. In this study, the protein expression of MAGE-A4 is comprehensively studied in patients with unresectable and/or metastatic solid cancers to identify indications of the highest unmet medical need for anti-MAGE-A4 therapy. FFPE tumor sections from 200 patients, predominantly HLA-A*02:01 positive (

Indexed as

biomarkerclinical trialpatient selectiontarget expressiontranslational analysis

Identifiers

PMID40151801
PMCPMC11947667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.