ArticleCureus2025
Paraneoplastic Anti-transcriptional Intermediary Factor 1γ (Anti-TIF1γ)-Positive Dermatomyositis Presenting as Dropped Head Syndrome: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Anti-transcriptional intermediary factor 1γ (anti-TIF1γ) antibody-positive dermatomyositis is a rare but significant subtype of dermatomyositis, often associated with malignancy. We present a case of a 66-year-old male with a history of heavy smoking, who was diagnosed with a locally advanced squamous cell carcinoma of the right cervical lymph nodes. After treatment with chemoradiotherapy, he developed dropped head syndrome and muscle weakness and was found to have elevated anti-TIF1γ antibodies, suggestive of paraneoplastic myositis. Despite aggressive treatment, the patient's condition deteriorated, leading to recurrent carcinoma and, ultimately, death due to respiratory infection. The rarity of this presentation and the diagnostic challenges are discussed, emphasizing the role of TIF1γ antibodies in diagnosing this rare entity.
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