ArticleCureus2025
The Improvement of Physical Function and Caregiver Burden by a Multimodal Intervention: A Case Study of Combined Exercise Therapy, Nutritional Guidance, and Hydrogen Gas Inhalation Therapy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
The objective of this exploratory case study was to examine the impact of a multifaceted intervention, which incorporated exercise therapy, nutritional guidance, and hydrogen gas inhalation, on the physical function and caregiver burden of an older female patient suspected of having sarcopenia. The methods employed included a three-month program of group exercise and individualized exercise sessions, three times per week, in addition to nutritional guidance and hydrogen gas inhalation therapy. The primary outcome measures included grip strength, walking speed, inflammatory/oxidative stress markers (c-reactive protein (CRP), interleukin-6 (IL-6), 8-hydroxy-2' -deoxyguanosine (8-OHdG)), and caregiver burden, which was assessed by the Family Caregiver Burden Scale (FCS). The results demonstrated that after a period of three months, there was an improvement in grip strength and walking speed. Concurrently, there was a decrease in CRP, IL-6, and 8-OHdG levels. The FCS score demonstrated a shift from the "severe" range to the "normal" range, suggesting a reduction in caregiver burden. The findings of this case study suggest that a multidisciplinary, multifaceted intervention combining exercise therapy, nutritional support, and hydrogen gas inhalation may be effective in enhancing physical function and reducing caregiver burden in older adults with suspected sarcopenia. However, further research is necessary to clarify the independent effects of hydrogen gas inhalation.
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