ReviewCureus2025
A Dive Into Cerebellar Dysfunction, Motor Deficits and GABAergic Signaling in Down Syndrome.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biogenesis and function of circular RNAs and their implications in the Down syndrome brain.Frontiers in genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down syndrome (DS) mouse models and DS human fetus studies clearly indicate severe neurogenesis impairment in the cerebellum. Clinical features of DS include motor dysfunction and cerebellar hypotrophy, with a particularly marked decrease in the number of granule cells (GCs). GCs are crucial for managing sensory communication within the cerebellum via mossy fibers and their interactions with Purkinje cells (PCs) and inhibitory interneurons. The current review discusses cerebellar alterations in DS and its impact on GABAergic transmission, bringing to light the impact on GABAergic signaling and its role in motor coordination dysfunction observed in individuals with DS. The findings highlight the significance of GABAergic transmission in the pathophysiology of DS and its potential as a target for therapeutic innervation. Moreover, understanding the disruptions in GABAergic signaling may provide insights into developing novel treatment strategies.
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Registered trials
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