ArticleCureus2025
Malignant Ossifying Fibromyxoid Tumor With Lung Metastasis: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal neoplasm of uncertain differentiation, typically exhibiting shell-like ossification and an indolent clinical course. However, some cases demonstrate aggressive behavior with local recurrence or metastasis. A 48-year-old Japanese man presented with a painless right thigh mass. He had been aware of it for 20 years and it had been enlarging slowly for the past year. Pathologic examination revealed that the removed 55-mm tumor chiefly consisted of spindle tumor cells proliferating, in the central area in a hypocellular fashion with scattered ossifications, and peripherally in a more cellular, plexiform-like perivascular fashion with nuclear pleomorphism and frequent mitosis (10 per 50 high-power fields). Tumor cells were positive for keratin, S-100 protein, α-smooth muscle actin, and MUC4, and the Ki67 labeling index was about 40%. S-100 protein immunoreactivity was decreased in the peripheral hypercellular areas. Two months after the surgery, a solitary lung metastasis was evident and was confirmed histologically. Additional fluorescence in situ hybridization examination of the primary tumor cells demonstrated
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