Evidence map›Paper›PMID 40151625›Full record

ArticleBioelectricity2023

Cx40 Suppresses Sprouting Angiogenesis

Edward K Looker, Femke J Aan, Christopher J Hatch, Christopher C W Hughes, Michelle L Matter, Jennifer S Fang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectricity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

  • Erratum issued
    2024
5 · Who and what money

Authors and funding

6 authors.

Edward K LookerDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, Louisiana, USA.
Femke J AanDepartment of Biochemistry and Molecular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Christopher J HatchDepartment of Biomedical Engineering, Henry Samueli School of Engineering, University of California-Irvine, Irvine, California, USA.
Christopher C W HughesDepartment of Biomedical Engineering, Henry Samueli School of Engineering, University of California-Irvine, Irvine, California, USA.
Michelle L MatterDepartment of Biochemistry and Molecular Biology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Jennifer S FangDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, Louisiana, USA.ORCID https://orcid.org/0000-0001-5703-2239

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood vessels are highly organized and form during development through a series of complex processes that include vasculogenesis, sprouting angiogenesis, and vessel remodeling. Several gap junction proteins (termed connexins, Cx)-including Cx40 (GJA5)-are expressed in vascular endothelium early during vessel development and are critical for establishment of a healthy vasculature. However, Cx40's specific role in regulating vessel growth remains uncertain: while previous studies have shown that developmental and cancer-associated neovascularization is reduced in Cx40-knockout mice, Cx40 knockout in zebrafish embryos enhances intersegmental vessel growth. Thus, in the current study, our aim was to identify Cx40's specific role in sprouting angiogenesis. First, we used a vessel-on-a-chip microphysiological model to confirm Cx40's overall necessity for microvessel network development. Next, we used the fibrin gel bead assay-a three-dimensional

Indexed as

bead assayblood vesselscell migrationcell proliferationconnexinsCx37Cx40Cx43endothelial cellsgap junctionsmicrophysiological modelsorgan-on-a-chipsprouting angiogenesis

Identifiers

PMID40151625
PMCPMC11949415

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.