Evidence map›Paper›PMID 40151623›Full record

ArticleOpen life sciences2025

Sleep architecture in Alzheimer's disease continuum: The deep sleep question.

Ioannis Foukarakis, Stefanos N Sampatakakis, Eirini Mamalaki, Andreas Kyrozis, Eva Ntanasi, Angeliki Tsapanou, Mary Yannakoulia, Konstantinos Rouskas, Nikolaos Scarmeas

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In one paragraph

Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Editorial: Sleep and neurodegeneration.Frontiers in sleep · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ioannis Foukarakis1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528, Athens, Greece.
Stefanos N Sampatakakis1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528, Athens, Greece.
Eirini Mamalaki1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528, Athens, Greece.
Andreas Kyrozis1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528, Athens, Greece.
Eva Ntanasi1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528, Athens, Greece.
Angeliki TsapanouThe Gertrude H. Sergievsky Center, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, 10032, United States of America.
Mary YannakouliaDepartment of Nutrition and Dietetics, Harokopio University, 17671 Athens, Greece.
Konstantinos RouskasInstitute of Applied Biosciences, Centre for Research & Technology Hellas, 54124 Thessaloniki, Greece.
Nikolaos Scarmeas1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, 11528, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As sleep appears to be closely related to cognitive status, we aimed to explore the association between the percentage of deep sleep, cognitive state, and the cerebrospinal fluid (CSF) biomarker amyloid-beta 42 in non-demented individuals. In this cross-sectional study, 90 non-demented participants from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration cohort underwent a one-night WatchPAT sleep evaluation. Participants were categorized by cognitive status (patients with mild cognitive impairment [MCI] or cognitively normal [CN] individuals) and CSF Aβ42 status (Aβ42 ≤ 1,030 pg/mL [A+] or Ab42 > 1,030 pg/mL [A-]). After controlling for age, sex, and years of education, a significant inverse association was found between the percentage of deep sleep and the odds of being classified as MCI compared to CN (OR = 0.86, 95% CI [0.76-0.97],

Indexed as

amyloid-beta 42CSF biomarkersmild cognitive impairmentsleep stagesWatchPAT

Identifiers

PMID40151623
PMCPMC11947663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.