Evidence map›Paper›PMID 40151613›Full record

ArticleFood science and biotechnology2025

The combination of Korean Sajabal mugwort (

Moon Jeong Son, Ga Yeon Lee, Jin Tae Kim, Yimeng Zhou, Jung Won Kwon, Jeongyoon Choi, Kyungsuk Park, Jungmin Lee, Yujin Ko, Shuai Qiu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Moon Jeong SonDepartment of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.
Ga Yeon LeeDepartment of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.
Jin Tae KimDepartment of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.
Yimeng ZhouDepartment of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.
Jung Won KwonDepartment of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.
Jeongyoon ChoiDepartment of Next Generation Applied Sciences, Graduate School, Sungshin Women's University, Seoul, 01133 Republic of Korea.
Kyungsuk ParkR&D Center, CINNAMON LAB Co. Ltd, Seoul, 06628 Republic of Korea.
Jungmin LeeR&D Center, CINNAMON LAB Co. Ltd, Seoul, 06628 Republic of Korea.
Yujin KoR&D Center, CINNAMON LAB Co. Ltd, Seoul, 06628 Republic of Korea.
Shuai QiuDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, 200072 China.
Jong Hun KimDepartment of Food Science and Biotechnology and Institute for Basic Sciences, Sungshin Women's University, Seoul, 01133 Republic of Korea.
Hong Jin LeeDepartment of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea.ORCID 0000-0001-7719-3101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the effects of Korean Sajabal mugwort extract (SME), green tea extract (GTE), and their optimized combination on improving blood flow. We first found that SME and GTE significantly suppressed TNF-α-induced ICAM-1 expression and enhanced endothelial nitric oxide synthase (eNOS) activation in EA.hy926 endothelial cells. Based on synergistic effects on regulation of IκBα, the mixture of SME and GTE at 9:1 ratio was determined as the optimal combination, and it also suppressed integrin LFA-1 expression, reducing leukocyte-endothelial cell interactions. The major components of SME (eupatilin and jaceosidin) and GTE (EGCG) were quantified, and their effects were consistent with the extracts. Furthermore, the mixture alleviated pulmonary vein occlusion, and decreased mRNA levels of ICAM-1, VCAM-1, P-selectin, and E-selectin in aortic tissue in collagen/epinephrine-induced thrombosis rat model. Taken together, the SME and GTE mixture effectively improved blow flow and may be a potent agent for preventing thrombosis and atherosclerosis.

Indexed as

Blood flowCell adhesion moleculesCombination optimizationeNOSGreen teaKorean Sajabal mugwort

Identifiers

PMID40151613
PMCPMC11937464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.