A case report of procedural management of an adult with morquio syndrome undergoing transcatheter aortic valve implantation.

Agustin Oneto, Rahul Sakhuja, Asishana Osho, Nathaniel B Langer, Matthew J Eagleton, Michael G Fitzsimons

Abstract readCase Reports

In one paragraph

Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Natural History of Morquio A Syndrome.Journal of inherited metabolic disease · 2026
Review
TAVI-in-TAVI in a patient with morquio syndrome: a case report.European heart journal. Case reports · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agustin OnetoDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.ORCID https://orcid.org/0009-0005-2497-2116

Rahul SakhujaCardiology Division, Department of Medicine, Interventional Cardiology Section, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Asishana OshoCardiac Surgery Division, Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Nathaniel B LangerCardiac Surgery Division, Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Matthew J EagletonVascular Surgery Division, Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Michael G FitzsimonsDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-4172-5561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Morquio syndrome is an autosomal recessive deficiency of Case summary: A 73-year-old woman with Morquio syndrome presented with one year of progressive dyspnoea and was found to have severe aortic stenosis on transthoracic echocardiogram. She previously underwent an attempted TAVI via transfemoral approach, which was aborted due to iliac artery dissection and occlusion. A multidisciplinary team opted for TAVI via a surgical femoral artery cut-down approach. She was last seen and recovering well three months post-procedure. Discussion: Musculoskeletal and cardiopulmonary manifestations of Morquio syndrome place patients at higher risk for procedural complications. As medical techniques improve and patients survive later into adulthood, increasing numbers will require aortic valve replacements to improve quality of life. This case highlights the challenges of aortic valve disease management in patients with Morquio syndrome, and suggests that TAVI can be safely performed using a surgical femoral cut-down approach.

Indexed as

Aortic valveCase reportGenetic disordersInherited metabolic disordersValve replacement

Identifiers

PMID40151589

DOI10.1093/ehjcr/ytaf117

PMCPMC11945293

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.