Evidence map›Paper›PMID 40151485›Full record

ArticleRoyal Society open science2025

Single enantiomer propeller-shaped polynuclear complexes as catalysts-proof-of-concept for enantioinduction in a Michael addition reaction.

Joe Maddocks, Mohan Mahesh, Stavroula I Sampani, Alexander C Dixon, Christian D-T Nielsen, Prashant Kumar, Geoffrey R Akien, John Spencer, Alaa Abdul-Sada, John F C Turner and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joe MaddocksDepartment of Chemistry, University of Sussex, Brighton, UK.
Mohan MaheshDepartment of Chemistry, Imperial College London, London, UK.
Stavroula I SampaniDepartment of Chemistry, University of Sussex, Brighton, UK.
Alexander C DixonDepartment of Chemistry, University of Sussex, Brighton, UK.
Christian D-T NielsenDepartment of Chemistry, Imperial College London, London, UK.
Prashant KumarDepartment of Chemistry, University of Sussex, Brighton, UK.
Geoffrey R AkienDepartment of Chemistry, Lancaster University, Lancaster, UK.
John SpencerDepartment of Chemistry, University of Sussex, Brighton, UK.
Alaa Abdul-SadaDepartment of Chemistry, University of Sussex, Brighton, UK.
John F C TurnerDepartment of Chemistry, University of Sussex, Brighton, UK.ORCID https://orcid.org/0000-0001-7584-0985
Alan C SpiveyDepartment of Chemistry, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-5114-490X
George E KostakisDepartment of Chemistry, University of Sussex, Brighton, UK.ORCID https://orcid.org/0000-0002-4316-4369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a family of propeller-shaped polynuclear metal complexes whose overall chirality is dictated by a single stereogenic centre within their component amino alcohol-ligand. These topologically intriguing complexes are readily prepared in enantiomerically pure form and are shown here to catalyse the conjugate addition of barbituric acids and their derivatives to nitroalkenes, with a catalyst loading of 1 mol%. Although only low levels of enantioinduction are observed, control experiments indicate that the enantioselectivity is dictated by the overall topology of the complex and not governed by binding to the tetrametallic entity, heralding a potentially new mode of catalysis.

Indexed as

enantioselective inductionMichael addition reactionpropeller-shaped complexes

Identifiers

PMID40151485
PMCPMC11947762

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.