ArticleFrontiers in nutrition2025
The association between the C-reactive protein-to-albumin-to-lymphocyte index and retinopathy: insights from a population-based study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The cally index as an indicator of inflammatory burden across clinical phases of familial mediterranean fever.Clinical rheumatology · 2026Article
- The Impact of the CALLY Index on All-Cause Mortality in Patients With Depression: A Longitudinal Analysis Using NHANES Data.Health science reports · 2026Article
- The C-reactive protein-albumin-lymphocyte index: a novel biomarker for metabolic dysfunction-associated fatty liver disease across three ethnic cohorts.Frontiers in public health · 2026Article
- Association between the C-reactive protein-albumin-lymphocyte index and cardiovascular incidence and mortality among patients with chronic kidney disease: a prospective study.Frontiers in immunology · 2026Article
- Association between NHHR and endometriosis and the mediating role of the CALLY index: a cross-sectional study based on NHANES.BMC women's health · 2025Article
- BMI mediates the association of CALLY index with liver steatosis and fibrosis.Scientific reports · 2025Article
- Association between the C-reactive protein-albumin-lymphocyte (CALLY) index and mortality in elderly patients with dysphagia requiring nutritional support.Frontiers in neurology · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Retinopathy is a multifactorial disease influenced by metabolism, immunity, inflammation, and other factors. The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel immunonutritional score that has shown promise in various health contexts. This study aims to investigate the association between the CALLY index and retinopathy risk, and to compare its predictive performance with other established inflammatory markers. Methods: Data from 5,439 participants in the 2005-2008 National Health and Nutrition Examination Survey (NHANES) were utilized. Multivariable-weighted logistic regression was employed to assess the association between the CALLY index and retinopathy risk. Additionally, the predictive performance of the CALLY index was compared with other inflammatory markers. Mediation analysis was conducted to explore potential mediating factors in the association between the CALLY index and retinopathy. Results: Multivariable-weighted logistic regression revealed a significant inverse association between the CALLY index and retinopathy risk (OR = 0.96, 95% CI = 0.94-0.98, Discussion: These findings highlight the CALLY index as a reliable, independent biomarker for retinopathy risk assessment, outperforming traditional inflammatory markers and oering potential clinical value for early identification of retinopathy in individuals with chronic diseases.
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