Evidence map›Paper›PMID 40151316›Full record

ArticleMediators of inflammation2025

The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation.

Chenyu Zhang, Hongyan Wei, Qiang Zhang, Haohong Zhan, Yuanzheng Lu, Yujie Li, Bo Li, Wen Huang, Feng Nian, Rong Liu and 2 more

Abstract read
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenyu ZhangDepartment of Emergency Medicine, The First Affiliated Hospital of Sun Yat-sen University, The 58th Zhongshan II Road, Guangzhou 510080, China.ORCID https://orcid.org/0000-0002-0142-2518
Hongyan WeiDepartment of Emergency Medicine, The First Affiliated Hospital of Sun Yat-sen University, The 58th Zhongshan II Road, Guangzhou 510080, China.
Qiang ZhangDepartment of Emergency Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, No.628, Zhenyuan Road, Guangming (New) Dist., Shenzhen 518107, China.
Haohong ZhanDepartment of Emergency Medicine, The First Affiliated Hospital of Sun Yat-sen University, The 58th Zhongshan II Road, Guangzhou 510080, China.
Yuanzheng LuDepartment of Emergency Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, No.628, Zhenyuan Road, Guangming (New) Dist., Shenzhen 518107, China.
Yujie LiDepartment of Emergency Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, No.628, Zhenyuan Road, Guangming (New) Dist., Shenzhen 518107, China.
Bo LiDepartment of Emergency Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, No.628, Zhenyuan Road, Guangming (New) Dist., Shenzhen 518107, China.
Wen HuangDepartment of Emergency Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Feng NianDepartment of Emergency Medicine, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Rong LiuThe First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chunlin HuDepartment of Emergency Medicine, The First Affiliated Hospital of Sun Yat-sen University, The 58th Zhongshan II Road, Guangzhou 510080, China.ORCID https://orcid.org/0000-0002-9510-0957
Jie ChenDepartment of Critical Care Medicine, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan 523059, Province Guangdong, China.ORCID https://orcid.org/0009-0005-9414-2804

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestHistone DeacetylasesInflammationAnimalsApoptosisGlial Fibrillary Acidic ProteinInterleukin-1betaMaleNF-kappa BRatsRats, WistarTumor Necrosis Factor-alphaGlial Fibrillary Acidic ProteinHistone DeacetylasesInterleukin-1betaNF-kappa BTumor Necrosis Factor-alphacardiopulmonary resuscitationITSA-1prognosissuberoylanilide hydroxamic acid (SAHA)

Identifiers

PMID40151316
PMCPMC11949605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.