Evidence map›Paper›PMID 40151263›Full record

ArticleJACS Au2025

Positive Charge in an Antimalarial Compound Unlocks Broad-Spectrum Antibacterial Activity.

Maria Braun-Cornejo, Mitchell Platteschorre, Vincent de Vries, Patricia Bravo, Vidhisha Sonawane, Mostafa M Hamed, Jörg Haupenthal, Norbert Reiling, Matthias Rottmann, Dennis Piet and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Braun-CornejoSpecs Compound Handling, B.V., Bleiswijkseweg 55, Zoetermeer 2712 PB, The Netherlands.ORCID https://orcid.org/0000-0003-2232-2388
Mitchell PlatteschorreSpecs Compound Handling, B.V., Bleiswijkseweg 55, Zoetermeer 2712 PB, The Netherlands.
Vincent de VriesSpecs Compound Handling, B.V., Bleiswijkseweg 55, Zoetermeer 2712 PB, The Netherlands.ORCID https://orcid.org/0009-0009-1350-7971
Patricia BravoSwiss Tropical and Public Health Institute, Kreuzstrasse 2, Allschwil 4123, Switzerland.ORCID https://orcid.org/0000-0001-5454-3826
Vidhisha SonawaneMicrobial Interface Biology, Research Center Borstel, Leibniz Lung Center, Borstel 23845, Germany.
Mostafa M HamedHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, Saarbrücken 66123, Germany.ORCID https://orcid.org/0000-0002-7374-6992
Jörg HaupenthalHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, Saarbrücken 66123, Germany.
Norbert ReilingMicrobial Interface Biology, Research Center Borstel, Leibniz Lung Center, Borstel 23845, Germany.ORCID https://orcid.org/0000-0001-6673-4291
Matthias RottmannSwiss Tropical and Public Health Institute, Kreuzstrasse 2, Allschwil 4123, Switzerland.
Dennis PietSpecs Compound Handling, B.V., Bleiswijkseweg 55, Zoetermeer 2712 PB, The Netherlands.
Peter MaasSpecs Compound Handling, B.V., Bleiswijkseweg 55, Zoetermeer 2712 PB, The Netherlands.
Eleonora DiamantiHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, Saarbrücken 66123, Germany.
Anna K H HirschDepartment of Pharmacy, Saarland University, Campus Building E8.1, Saarbrücken 66123, Germany.ORCID https://orcid.org/0000-0001-8734-4663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we synthesized a library of eNTRy-rule-compliant compounds by introducing ionizable nitrogen atoms to an antimalarial compound. These positively charged derivatives gained activity against both Gram-negative and -positive bacteria,

Identifiers

PMID40151263
PMCPMC11938010

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.