Evidence map›Paper›PMID 40151232›Full record

ArticleJACS Au2025

Photoredox-Catalyzed Radical Cyclization of Unactivated Alkene-Substituted β-Ketoesters Enabled Asymmetric Total Synthesis of Tricyclic Prostaglandin D

Miao Xiao, Qiaoli Shang, Liuyang Pu, Zheyuan Wang, Lei Zhu, Zhen Yang, Jun Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miao XiaoSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.
Qiaoli ShangSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.
Liuyang PuSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.ORCID https://orcid.org/0000-0002-6129-7827
Zheyuan WangState Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Lei ZhuCollege of Pharmacy, Third Military Medical University, Chongqing 200038, China.ORCID https://orcid.org/0000-0002-7870-8469
Zhen YangState Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.ORCID https://orcid.org/0000-0001-8036-934X
Jun HuangSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.ORCID https://orcid.org/0000-0003-1861-2390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regio- and stereoselective photoredox-catalyzed cyclizations of alkene-substituted β-ketoesters have been accomplished for the synthesis of polyfunctionalized cyclopentanones. This was achieved using 2,3,5,6-tetrakis(carbazol-9-yl)-1,4-dicyanobenzene (4CzTPN) and 2,4,6-triisopropyl-thiophenol as cocatalysts under illumination of a blue-light-emitting-diode at ambient temperature. The developed chemistry was successfully applied in the enantioselective total synthesis of the tricyclic prostaglandin D

Identifiers

PMID40151232
PMCPMC11937966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.