Evidence map›Paper›PMID 40151183›Full record

ArticleFrontiers in pediatrics2025

Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI.

Carmen Streibel, Grzegorz Bauman, Oliver Bieri, Orso Pusterla, Enno Stranzinger, C Corin Willers, Marion Curdy, Carmen Casaulta, Bettina Sarah Frauchiger, Insa Korten and 4 more

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Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carmen StreibelDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Grzegorz BaumanDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland.
Oliver BieriDepartment of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland.
Orso PusterlaDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Enno StranzingerDepartment of Diagnostic and Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, Switzerland.
C Corin WillersDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marion CurdyDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Carmen CasaultaDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Bettina Sarah FrauchigerDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Insa KortenDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sophie YammineDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Yasmin SalemDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Philipp LatzinDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Elisabeth KieningerDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Functional imaging of the lungs enables a spatially resolved examination of pulmonary ventilation and perfusion. Non-contrast-enhanced (NCE) magnetic resonance imaging (MRI) techniques do not require specialized set-ups (e.g., hyperpolarized gases), but are applicable on standard clinical MRI scanners. Since patients are not exposed to ionizing radiation during the examinations, NCE-MRI is highly attractive for use in pediatrics, especially in children with chronic lung diseases requiring repeated follow-up measurements. Study design: We report on our own experience of more than 900 NCE-MRI measurements in children over seven years using matrix pencil decomposition (MP-)MRI. We present original data, i.e., clinical cases in which MP-MRI helped in clinical decision-making together with valuable practical points. Results: At our center, an optimized workflow including a child-friendly setting and automated provision of outcome protocols led to great acceptance of functional NCE-MRI in patients and clinicians. Within this setting, regular MP-MRI measurements were successfully implemented into clinical routine and proved to be very helpful for surveillance and specific clinical decision-making. We present exemplary cases illustrating the potential of NCE-MRI as a diagnostic tool. Conclusion: In this article, we summarize our unique experience of a large number of MP-MRI measurements. We give an overview on our workflow including standardized and automated analysis and reporting. The exemplary cases from different disease groups illustrate its value in the clinical setting. In conclusion, visualizing regional functional deficits and respective underlying pathophysiological nature of lung impairment seems promising for increasing use of NCE-MRI in the future.

Indexed as

childrenfunctional lung MRIlung functionMP-MRIpulmonology

Identifiers

PMID40151183
PMCPMC11947945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.