Evidence map›Paper›PMID 40151144›Full record

ArticleActa biochimica et biophysica Sinica2025

A positive feedback loop between FOSB and miR-133b controls colon cancer cell proliferation.

Wanwan Li, Qionggui Hu, Changwei Lin, Xiaorong Li, Yang Bai, Min Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanwan LiDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Qionggui HuDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Changwei LinDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Xiaorong LiDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Yang BaiDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.
Min MaDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOSB, a member of the FOS gene family, forms heterodimers with JUN family proteins to engage in diverse cellular processes. Its biological impacts vary among different types of tumors, yet its specific function in colon cancer (CC) remains ambiguous. In this study, quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC) are applied to measure FOSB expression levels, followed by an analysis of the association between FOSB expression and patients' clinical parameters.

Indexed as

Cell ProliferationColonic NeoplasmsFeedback, PhysiologicalMicroRNAsProto-Oncogene Proteins c-fosAnimalsApoptosisCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudePromoter Regions, GeneticFOSB protein, humanMicroRNAsMIRN133 microRNA, humanProto-Oncogene Proteins c-foscolon cancerFOSBmiR-133bPOU2F1proliferation

Identifiers

PMID40151144
PMCPMC12368540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.