Evidence map›Paper›PMID 40151132›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Effect of acupuncture on brain activity in patients with decreasing ovarian reserve: a resting-state functional magnetic resonance imaging study.

Bai Tianyu, Yang Jiaen, Yin Liang, L I Jinling, Liu Jianxian, L I Zongchang, Sun Zeming, Jia Ning, X U Chengchao

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bai TianyuDepartment of Acupuncture, Moxibustion and Massage, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China.
Yang JiaenDepartment of Traditional Chinese Medicine, People's Hospital of Gaoming District of Foshan City, Foshan 528500, China.
Yin LiangDepartment of Imaging, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China.
L I JinlingCollege of Acupuncture, Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Liu JianxianDepartment of Imaging, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China.
L I ZongchangDepartment of Imaging, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China.
Sun ZemingDepartment of Imaging, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China.
Jia NingDepartment of Traditional Chinese Medicine, People's Hospital of Gaoming District of Foshan City, Foshan 528500, China.
X U ChengchaoCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Funding

Clinical Science and Technology Innovation Program of Jinan Science and Technology Bureau: Study on the Regulatory Mechanism of Menstrual Regulation and Pregnancy Promotion Acupuncture Method based on rs-functional Magnetic Resonance Imaging Technology on the Brain Function Network of Decreasing Ovarian Reserve Patients 202225059Innovation and Development Joint Fund of Natural Science Foundation of Shandong Province: based on the Nuclear Factor-erythroid 2 Related Factor 2/AU-rich Element Antioxidant Pathway, the Effect and Mechanism of Menstrual Stimulation Acupuncture on in vitro Fertilization and Embryo Transfer Pregnancy Outcomes in Poor Ovarian Response Patients were Studied ZR2022LZY008Qilu Health and Health Leading Talents Training Project 3 [2020]Shandong Provincial Traditional Chinese Medicine High-level Personnel Training Program Supported by Special Funds 6 [2021]Shandong Traditional Chinese Medicine Science and Technology Development Plan Project: a Multimodal Neuroimaging Study of Menstrual Stimulation Acupuncture in Patients with Polycystic Ovary Syndrome Q-2022099Shandong Traditional Chinese Medicine Science and Technology Development Plan Project: based on the Immunoregulation of Treg Cells, the Mechanism of Menstruation and Pregnancy Promotion Injection in the Treatment of Early-onset Ovarian Insufficiency was Explored B-2022002
6 · The paper itself

Abstract

objectiveTo examine the variations in brain regions among individuals with decreasing ovarian reserve (DOR) compared to healthy controls using resting-state functional magnetic resonance imaging (rs-fMRI), and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.

methodsTwenty patients diagnosed with DOR (DOR group) and twenty healthy controls (HC group) who underwent rs-fMRI scans were included. The DOR group received acupuncture and underwent a subsequent rs-fMRI scan. Amplitude of low-frequency fluctuations (ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups, and to evaluate the immediate effects of acupuncture on DOR patients' brain regions. Common brain regions were identified as seed points for functional connectivity (FC) analysis.

resultsIn this study, a total of 20 HCs and 20 patients with DOR were initially enrolled. However, due to incomplete personal information, three participants were removed from the HC group. Additionally, two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan, leading to their exclusion due to excessive head movement parameters. Consequently, 17 HCs and 16 DOR patients completed the entire study protocol. Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus (ITG) and middle temporal gyrus (MTG), while ALFF values in the bilateral superior frontal gyrus (SFG), middle frontal gyrus (MFG), and left inferior frontal gyrus (IFG) were decreased compared to HCs. Following acupuncture intervention, ALFF values in the left SFG, MFG, and supplementary motor area (SMA) of DOR patients increased. Furthermore, functional connectivity (FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.

conclusionThis study highlights abnormal neural activity in the SFG, MFG, IFG, and ACC in DOR patients compared to HCs. Acupuncture was found to regulate the activity of the SFG, bringing it closer to normal levels, and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.

Indexed as

Acupuncture TherapyBrainOvarian ReserveAdultFemaleHumansMagnetic Resonance ImagingYoung Adultacupuncturebrain activitymagnetic resonance imagingovarian reserve

Identifiers

PMID40151132
PMCPMC11955760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.