ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Integrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models.
Tan Xiying, G U Ruxin, Tao Jing, Zhang Yu, Sun RuiQian, Yin Gang, Zhang Shuo, Tang Decai
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Tan XiyingDepartment of Pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
G U RuxinDepartment of Pain Management, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China.
Tao JingSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Zhang YuSchool of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Sun RuiQianSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yin GangSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhang ShuoDepartment of Pharmacy, Nantong Hospital of Traditional Chinese Medicine, Nantong, 226001, China.
Tang DecaiSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Funding
National Natural Science Foundation of China Youth Found Project: Anti-Colorectal Cancer Metastasis Mechanism of Huangqi (Radix Astragali Mongolici)-Ezhu (Rhizoma Curcumae Phaeocaulis) According to the Hypoxia-Inducible Factor 2 Alpha/β-Catenin Cross-Talk Which Influence the Colon Tumor Stem Cells in Hypoxia Microenvironment 82003961National Natural Science Foundation of China Youth Found Project: the Mechanism of the Compatibility of Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis) on the Early Metastasis of Hepatocellular Carcinoma Mediated by Cancer Associated Fibroblasts 82104408Science and Technology Development Project of Traditional Chinese Medicine in Jiangsu Province: Mechanism of Huangqi (Radix Astragali Mongolici)-Ezhu (Rhizoma Curcumae Phaeocaulis) Herb Pair on the Inhibition of Colon Cancer Metastasis Through the Wnt/β-catenin Pathway YB201921Science Foundation of China Project: Involvement of Hypoxia Inducible Factor-1α Signal in Huangqi (Radix Astragali Mongolici)-Ezhu (Rhizoma Curcumae Phaeocaulis) Combination Induced Remolding of Tumor Hypoxic Microenvironment 82074035
6 · The paper itself
Abstract
objectiveTo evaluate the effects of Huangqi (
methodsThe anti-tumor effects of HQEZ were evaluated in colorectal cancer models both
resultsHQEZ significantly enhanced the anti-tumor activity of 5-FU
conclusionHQEZ has synergistic effects on the anti-tumor activity of 5-FU in the treatment of colorectal cancer both
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Integrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models. · full record | OpenQuestion